A Comprehensive Review on the Current Vaccines and Their Efficacies to Combat SARS-CoV-2 Variants

被引：12

作者：

Rabaan, Ali A. ^{[1
,2
,3
]}

Al Mutair, Abbas ^{[4
,5
,6
,7
]}

Hajissa, Khalid ^{[8
]}

Alfaraj, Amal H. ^{[9
]}

Al-Jishi, Jumana M. ^{[10
]}

Alhajri, Mashael ^{[11
]}

Alwarthan, Sara ^{[11
]}

Alsuliman, Shahab A. ^{[12
]}

Al-Najjar, Amal H. ^{[13
]}

Al Zaydani, Ibrahim A. ^{[14
]}

Al-Absi, Ghadeer Hassan ^{[15
]}

Alshaikh, Sana A. ^{[16
]}

Alkathlan, Mohammed S. ^{[17
]}

Almuthree, Souad A. ^{[18
]}

Alawfi, Abdulsalam ^{[19
]}

Alshengeti, Amer ^{[19
,20
]}

Almubarak, Fatimah Z. ^{[21
]}

Qashgari, Mohammed S. ^{[22
]}

Abdalla, Areeg N. K. ^{[23
]}

Alhumaid, Saad ^{[24
]}

机构：

[1] Johns Hopkins Aramco Healthcare, Mol Diagnost Lab, Dhahran 31311, Saudi Arabia

[2] Alfaisal Univ, Coll Med, Riyadh 11533, Saudi Arabia

[3] Univ Haripur, Dept Publ Hlth & Nutr, Haripur 22610, Pakistan

[4] Almoosa Specialist Hosp, Res Ctr, Al Hasa 36342, Saudi Arabia

[5] Princess Norah Bint Abdulrahman Univ, Coll Nursing, Riyadh 11564, Saudi Arabia

[6] Wollongong Univ, Sch Nursing, Wollongong, NSW 2522, Australia

[7] Prince Sultan Mil Coll Hlth Sci, Nursing Dept, Dhahran 33048, Saudi Arabia

[8] Univ Sains Malaysia, Sch Med Sci, Dept Med Microbiol & Parasitol, Kubang Kerian 16150, Malaysia

[9] Abgaiq Gen Hosp, Pediat Dept, Eastern Hlth Cluster 1, Abgaiq 33261, Saudi Arabia

[10] Qatif Cent Hosp, Internal Med Dept, Qatif 635342, Saudi Arabia

[11] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Internal Med, Dammam 34212, Saudi Arabia

[12] Dammam Med Complex, Dept Internal Med, Infect Dis Div, Dammam 32245, Saudi Arabia

[13] Drug & Poison Informat Ctr, Secur Forces Hosp Program, Pharm Dept, Riyadh 3643, Saudi Arabia

[14] Abha Matern & Children Hosp, Dept Pediat Infect Dis, Abha 62526, Saudi Arabia

[15] Alfaisal Univ, Coll Pharm, Dept Pharm Practice, Riyadh 325476, Saudi Arabia

[16] Matern & Children Hosp, Diagnost Virol Lab, Eastern Hlth Cluster, Dammam 32253, Saudi Arabia

[17] King Fahad Specialist Hosp, Infect Dis Dept, Buraydah 52382, Saudi Arabia

[18] King Abdullah Med City, Dept Infect Dis, Mecca 43442, Saudi Arabia

[19] Taibah Univ, Coll Med, Dept Pediat, Al Madinah 41491, Saudi Arabia

[20] Prince Mohammad Bin Abdulaziz Hosp, Dept Infect Prevent & Control, Natl Guard Hlth Affairs, Al Madinah 41491, Saudi Arabia

[21] Family Med Acad, Dept Family Med, Dammam 36365, Saudi Arabia

[22] Saudi Publ Hlth Author, Communicable Dis Prevent Dept, Riyadh 13354, Saudi Arabia

[23] Saudi German Hosp, Dept Intens Care Unit, Dammam 32313, Saudi Arabia

[24] Minist Hlth, Al Ahsa Hlth Cluster, Adm Pharmaceut Care, Al Hasa 31982, Saudi Arabia

来源：

VACCINES | 2022年 / 10卷 / 10期

关键词：

SARS-CoV-2; viral variants; vaccine; immunity; mutations; MESSENGER-RNA VACCINATION; BNT162B2; VACCINE; PFIZER-BIONTECH; UNITED-STATES; COVID-19; HOSPITALIZATIONS; IMMUNOGENICITY; INFECTION; MULTICENTER; PLATFORMS;

D O I：

10.3390/vaccines10101655

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since the first case of Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, SARS-CoV-2 infection has affected many individuals worldwide. Eventually, some highly infectious mutants-caused by frequent genetic recombination-have been reported for SARS-CoV-2 that can potentially escape from the immune responses and induce long-term immunity, linked with a high mortality rate. In addition, several reports stated that vaccines designed for the SARS-CoV-2 wild-type variant have mixed responses against the variants of concern (VOCs) and variants of interest (VOIs) in the human population. These results advocate the designing and development of a panvaccine with the potential to neutralize all the possible emerging variants of SARS-CoV-2. In this context, recent discoveries suggest the design of SARS-CoV-2 panvaccines using nanotechnology, siRNA, antibodies or CRISPR-Cas platforms. Thereof, the present comprehensive review summarizes the current vaccine design approaches against SARS-CoV-2 infection, the role of genetic mutations in the emergence of new viral variants, the efficacy of existing vaccines in limiting the infection of emerging SARS-CoV-2 variants, and efforts or challenges in designing SARS panvaccines.

引用

页数：25

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