3-(Substituted Aryl)-1-benzofuranyl-2-propenones: Antimicrobial Properties of Some Chalcones-Type Compounds and their 2-Pyrazoline Derivatives

被引：16

作者：

Coskun, Demet ^{[1
]}

Ahmedzade, Misir ^{[1
]}

Kirbag, Sevda ^{[2
]}

机构：

[1] Firat Univ, Fac Sci & Arts, Dept Chem, TR-23119 Elazig, Turkey

[2] Firat Univ, Fac Sci & Arts, Dept Biol, TR-23119 Elazig, Turkey

来源：

E-JOURNAL OF CHEMISTRY | 2011年 / 8卷 / 04期

关键词：

Benzofuran; Chalcone; Pyrazoline; Antimicrobial; Antifungal; BIOLOGICAL EVALUATION; PYRAZOLINE DERIVATIVES; PART;

D O I：

10.1155/2011/806854

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Acetylbenzofuran on condensation with furan-2-carboxaldehyde and pyrrole-2-carboxaldehyde in methanolic KOH solution yielded the corresponding benzofuran chalcones. These two compounds and nine benzofuran chalcones were synthesized before, were further reacted with hydrazine hydrate in ethanol which led to the formation of 2-pyrazoline derivatives. All the synthesized compounds were characterized by elemental analysis, melting point determination, infrared spectroscopy and nuclear magnetic resonance spectroscopy. Nine chalcone-type compounds and eleven 2-pyrazolines were evaluated for their biological activities against the six bacteria and the three yeast and it was seen that thirteen compounds showed activity. Four of them are chalcone-type compounds showed more or less activity

引用

页码：1574 / 1581

页数：8

共 23 条

[1] Syntheses and biological activities of chalcone and 1,5-benzothiazepine derivatives:: Promising new free-radical scavengers, and esterase, urease, and α-glucosidase inhibitors [J].

Ansari, FL ;

Umbreen, S ;

Hussain, L ;

Makhmoor, T ;

Nawaz, SA ;

Lodhi, MA ;

Khan, SN ;

Shaheen, F ;

Choudhary, MI ;

Atta-ur-Rahman .

CHEMISTRY & BIODIVERSITY, 2005, 2 (04) :487-496

[2]

Babu V. Harinadha, 2007, Indian Journal of Pharmaceutical Sciences, V69, P470

[3] Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents [J].

Bhat, BA ;

Dhar, KL ;

Puri, SC ;

Saxena, AK ;

Shanmugavel, M ;

Qazi, GN .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (12) :3177-3180

[4]

BILGIN AA, 1993, ARZNEIMITTEL-FORSCH, V43-2, P1041

[5]

Chan ECZ., 1993, LAB EXERCISES MICROB, P225

[6] LICOCHALCONE-A, A NEW ANTIMALARIAL AGENT, INHIBITS IN-VITRO GROWTH OF THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM AND PROTECTS MICE FROM P-YOELII INFECTION [J].

CHEN, M ;

THEANDER, TG ;

CHRISTENSEN, SB ;

HVIID, L ;

ZHAI, L ;

KHARAZMI, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (07) :1470-1475

[7] 3-(Substituted Aryl)-1-(benzofuran-2-yl)-2-propenones, Part 1: Synthesis and Characterization of Some Novel Chalcones [J].

Coskun, Demet ;

Ahmedzade, Misir .

SYNTHETIC COMMUNICATIONS, 2008, 38 (21) :3613-3622

[8] Structure-biological activity relationship of synthetic trihydroxilated chalcones [J].

Devia, CM ;

Pappano, NB ;

Debattista, NB .

REVISTA DE MICROBIOLOGIA, 1998, 29 (04) :307-310

[9]

Dominguez Jose N., 2005, Farmaco (Lausanne), V60, P307, DOI 10.1016/j.farmac.2005.01.005

[10]

Jayamma Y, 1996, INDIAN J HETEROCY CH, V6, P111

← 1 2 3 →