Muscarinic toxins

被引：35
作者：
Servent, Denis [1 ]
Blanchet, Guillaume [1 ]
Mourier, Gilles [1 ]
Marquer, Catherine [1 ]
Marcon, Elodie [1 ]
Fruchart-Gaillard, Carole [1 ]
机构：
[1] CEA, Inst Biol & Technol iBiTecS, Serv Ingn Mol Prot SIMOPRO, F-91191 Gif Sur Yvette, France
来源：
TOXICON | 2011年 / 58卷 / 6-7期
关键词：
Muscarinic toxins; Muscarinic receptors; Three-finger fold toxins; GPCRs; AMINO-ACID-SEQUENCE; MAMBA DENDROASPIS-ANGUSTICEPS; ACETYLCHOLINE-RECEPTOR MACHR; SNAKE-VENOM; GREEN MAMBA; MOLECULAR EVOLUTION; PHOSPHOLIPASE A(2); ALPHA-NEUROTOXINS; ADENYLYL-CYCLASE; 3-FINGER TOXIN;
D O I：
10.1016/j.toxicon.2011.08.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Muscarinic toxins isolated from the venom of Dendroaspis snakes may interact with a high affinity, large selectivity and various functional properties with muscarinic receptors. Therefore, these toxins are invaluable tools for studying the physiological role, molecular functioning and structural organization of the five subtypes of these G-Protein Coupled Receptors. We review the data on the most relevant results dealing with the isolation/identification, mode of action, structure/function and exploitation of these toxins and finally highlight the unresolved issues related to their pharmacological studies. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：455 / 463
页数：9
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