Field experiments were conducted in the wet seasons of 2005 and 2006 to evaluate the effect of pre-emergence application of herbicides on cowpea. A mixture of metolachlor and prometryn at 1.25 + 0.08 kg a.i./ha was consistent in better growth and seed yield. However, application of mixtures of metolachlor and terbutryn at 0.99 + 0.50 kg a.i./ha and ametryn and terbutryn at 1.60 + 1.00 kg a.i./ha gave lower vigour score of the crop, higher crop injury, smaller canopy spread and lower seed yield. It can be concluded that the metolachlor and prometryn mixture gave good selective weed control and can be used instead of hand weeding in cowpea in northern Nigeria. (C) 2008 Elsevier Ltd. All rights reserved.