Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents

被引：67

作者：

Poulose, Aby Cheruvathoor ^{[1
]}

Veeranarayanan, Srivani ^{[1
]}

Mohamed, M. Sheikh ^{[1
]}

Nagaoka, Yutaka ^{[1
]}

Aburto, Rebeca Romero ^{[2
]}

Mitcham, Trevor ^{[3
]}

Ajayan, Pulickel M. ^{[2
]}

Bouchard, Richard R. ^{[3
]}

Sakamoto, Yasushi ^{[4
]}

Yoshida, Yasuhiko ^{[1
]}

Maekawa, Toru ^{[1
]}

Kumar, D. Sakthi ^{[1
]}

机构：

[1] Toyo Univ, Grad Sch Interdisciplinary New Sci, Bio Nano Elect Res Ctr, Kawagoe, Saitama 3508585, Japan

[2] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77054 USA

[4] Saitama Med Univ, Div Analyt Sci, Biomed Res Ctr, Saitama 3500495, Japan

来源：

NANOSCALE | 2015年 / 7卷 / 18期

基金：

美国国家卫生研究院;

关键词：

DRUG-DELIVERY; MULTIFUNCTIONAL NANOPARTICLES; TARGETING STRATEGIES; SILICA NANOPARTICLES; QUANTUM DOTS; CANCER; ABLATION; NANOMEDICINE; STATISTICS; RIBOTOXIN;

D O I：

10.1039/c4nr07139e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo-and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.

引用

页码：8378 / 8388

页数：11

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