Hepatitis B virus large surface protein in serum as a candidate biomarker for evaluating hepatitis B virus infection

被引：11
|
作者：
Wang, Nian-Yue [2 ]
Zhang, Dai [1 ]
Zhao, Wei [2 ]
Li, Bo-An [3 ]
Lin, Chang-Qin [4 ]
机构：
[1] Henan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Clin Lab, Zhengzhou 450000, Henan Province, Peoples R China
[2] Southeast Univ, Affiliated Hosp 2, Dept Clin Lab, Nanjing, Peoples R China
[3] 302 Hosp PLA, Ctr Clin Lab, Beijing, Peoples R China
[4] Beijing Hotgen Biotech Co Ltd, Beijing, Peoples R China
来源：
CLINICAL BIOCHEMISTRY | 2011年 / 44卷 / 14-15期
关键词：
Hepatitis B virus; Large surface protein; HBV DNA; Hepatitis B surface antigens; Chronic hepatitis B; PRE-S-REGION; ANTIGEN; PARTICLES; REPLICATION; VARIANTS; SEQUENCE; MARKER; LIVER; MICE; DNA;
D O I：
10.1016/j.clinbiochem.2011.07.002
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Aim: To develop a sandwich enzyme-linked immunosorbent assay (ELISA) for the detection of serum hepatitis B virus large surface protein (HBV-LP), and study the clinical value of HBV-LP. Methods: Serum HBV-LP levels and a panel of other HBV markers were investigated in a large population of patients with chronic HBV. The clinical value of HBV-LP was evaluated by comparing the coincidence of detection of HBV markers and the change of serum HBV-LP level during antiviral therapy. Results: The ELISA was found to be sensitive and specific for the detection of HBV-LP. Serum HBV-LP level was positively correlated with HBV DNA (r=0.743) in HBV patients. Among the five HBV markers tested, HBV-LP displayed the highest coincidence rate (94.7%) with HBV DNA. Conclusions: Serum HBV-LP was strongly correlated with HBV DNA. This ELISA therefore offers a promising approach for the diagnosis and treatment monitoring of HBV patients. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：1199 / 1204
页数：6
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