Pyrolytic carbon coating for cytocompatibility of titanium oxide nanoparticles: a promising candidate for medical applications

被引：17

作者：

Behzadi, Shahed ^{[1
,2
,3
]}

Imani, Mohammad ^{[2
]}

Yousefi, Mohammad ^{[4
]}

Galinetto, Pietro ^{[5
,6
]}

Simchi, Abdolreza ^{[1
]}

Amiri, Houshang ^{[5
,6
,7
]}

Stroeve, Pieter ^{[8
]}

Mahmoudi, Morteza ^{[3
,9
]}

机构：

[1] Sharif Univ Technol, Dept Mat Sci & Engn, Tehran, Iran

[2] Iran Polymer & Petrochem Inst, Novel Drug Delivery Syst Dept, Tehran, Iran

[3] Pasteur Inst Iran, Natl Cell Bank, Tehran, Iran

[4] Iran Polymer & Petrochem Inst, Gas Convers Dept, Tehran, Iran

[5] Univ Pavia, Dept Phys A Volta, I-27100 Pavia, Italy

[6] Univ Pavia, CNISM INFM Unit, I-27100 Pavia, Italy

[7] Univ Milan, DISMAB, Dept Mol Sci Appl Biosyst, I-20134 Milan, Italy

[8] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA

[9] Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran, Iran

来源：

NANOTECHNOLOGY | 2012年 / 23卷 / 04期

关键词：

CHEMICAL-VAPOR-DEPOSITION; IN-VIVO; FILMS; HEMOCOMPATIBILITY; TOXICITY;

D O I：

10.1088/0957-4484/23/4/045102

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Nanoparticles for biomedical use must be cytocompatible with the biological environment that they are exposed to. Current research has focused on the surface functionalization of nanoparticles by using proteins, polymers, thiols and other organic compounds. Here we show that inorganic nanoparticles such as titanium oxide can be coated by pyrolytic carbon (PyC) and that the coating has cytocompatible properties. Pyrolization and condensation of methane formed a thin layer of pyrolytic carbon on the titanium oxide core. The formation of the PyC shell retards coalescence and sintering of the ceramic phase. Our MTT assay shows that the PyC-coated particles are cytocompatible at employed doses.

引用

页数：7

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