Copper(i) halide and palladium(ii) chloride complexes of 4-thioxo[1,3,5]oxadiazocines: synthesis, structure and antibacterial activity

被引：8

作者：

Kuzovlev, Andrey S. ^{[1
]}

Volkova, Daria A. ^{[1
]}

Parfenova, Irina V. ^{[1
]}

Kulakov, Ivan V. ^{[1
]}

Shkirdova, Alena O. ^{[2
]}

Zamilatskov, Ilya A. ^{[2
]}

Chernyshev, Vladimir V. ^{[2
,3
]}

Rybakov, Victor B. ^{[3
]}

Tyurin, Vladimir S. ^{[2
]}

Fefilov, Nikolay N. ^{[1
]}

Vasilchenko, Alexey S. ^{[4
]}

机构：

[1] Univ Tyumen, Inst Chem, Perekopskaya Str 15a, Tyumen 625003, Russia

[2] RAS, Lab New Physicochem Problems, AN Frumkin Inst Phys Chem & Electrochem, Leninsky Prospect 31-4, Moscow 119071, Russia

[3] Moscow MV Lomonosov State Univ, Dept Chem, Leninskie Gory Str 1-3, Moscow 119991, Russia

[4] Univ Tyumen, Inst Environm & Agr Biol X BIO, Lab Antimicrobial Resistance, Lenina Str 25, Tyumen 625003, Russia

来源：

NEW JOURNAL OF CHEMISTRY | 2020年 / 44卷 / 19期

关键词：

BIGINELLI-TYPE; DERIVATIVES; AGENTS; ZINC; DIHYDROPYRIMIDINES; TRANSFORMATIONS; MECHANISMS; PYRIMIDINE; ANTIFUNGAL; TRANSPORT;

D O I：

10.1039/c9nj05958j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper(i) halide and palladium(ii) chloride complexes with tricyclic monastrol analogs containing the oxadiazocine ring have been synthesized and studied. The structures of the complexes were investigated with IR, NMR and UV spectroscopy. Two complexes, [Cu(L-1)(2)Cl] and [Pd(L-1)(2)Cl-2], were structurally characterized by X-ray single-crystal and powder diffraction respectively. All the obtained coordination compounds were mononuclear. The ligands were coordinated with copper(i) and palladium(ii) only via the soft sulfur atoms of thiocarbamide fragments, while the harder nitrogen and oxygen atoms remained uncoordinated. The palladium center was coordinated by two Cl ions and two S atoms from two 4-thioxo[1,3,5]oxadiazocine ligands in a distorted square-planar geometry. Copper(i) formed a trigonal planar geometry. The complexes demonstrated significant antibacterial activity towards the Escherichia coli K12 TG 1 bacterial strain in contrast to the free ligands, which didn't show any noticeable activity.

引用

页码：7865 / 7875

页数：11

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