Role of the vaginally administered aromatase inhibitor anastrozole in women with rectovaginal endometriosis: a pilot study

被引:72
作者
Hefler, LA [1 ]
Grimm, C [1 ]
van Trotsenburg, M [1 ]
Nagele, F [1 ]
机构
[1] Med Univ Vienna, Dept Obstet & Gynecol, Div Endocrinol & Reprod Med, A-1090 Vienna, Austria
关键词
D O I
10.1016/j.fertnstert.2005.04.059
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
In the present nonrandomized pilot study we determined the role of the vaginally administered aromatase inhibitor anastrozole (0.25 mg anastrozole/d for 6 months) in the treatment of women with histologically proven rectovaginal endometriosis. In a series of 10 patients, dysmenorrhea, physical and social functioning, but not chronic pelvic pain and dyspareunia, improved during therapy.
引用
收藏
页码:1033 / 1036
页数:4
相关论文
共 21 条
[1]   Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study [J].
Ailawadi, RK ;
Jobanputra, S ;
Kataria, M ;
Gurates, B ;
Bulun, SE .
FERTILITY AND STERILITY, 2004, 81 (02) :290-296
[2]   Why consider vaginal drug administration? [J].
Alexander, NJ ;
Baker, E ;
Kaptein, M ;
Karck, U ;
Miller, L ;
Zampaglione, E .
FERTILITY AND STERILITY, 2004, 82 (01) :1-12
[3]   Relationship between endometriotic foci and nerves in rectovaginal endometriotic nodules [J].
Anaf, V ;
Simon, P ;
Nakadi, IE ;
Fayt, I ;
Buxant, F ;
Simonart, T ;
Peny, MO ;
Noel, JC .
HUMAN REPRODUCTION, 2000, 15 (08) :1744-1750
[4]   Molecular basis for treating endometriosis with aromatase inhibitors [J].
Bulun, SE ;
Zeitoun, KM ;
Takayama, K ;
Sasano, H .
HUMAN REPRODUCTION UPDATE, 2000, 6 (05) :413-418
[5]   Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis [J].
Bulun, SE ;
Zeitoun, K ;
Takayama, K ;
Noble, L ;
Michael, D ;
Simpson, E ;
Johns, A ;
Putman, M ;
Sasano, H .
ENDOCRINE-RELATED CANCER, 1999, 6 (02) :293-301
[6]   Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance [J].
Bulun, SE ;
Zeitoun, KM ;
Takayama, K ;
Sasano, H .
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2000, 25 (01) :35-42
[7]  
Carter J E, 1998, JSLS, V2, P129
[8]   Laparoscopically assisted vaginal management of deep endometriosis infiltrating the rectovaginal septum [J].
Chapron, C ;
Jacob, S ;
Dubuisson, JB ;
Vieira, M ;
Liaras, E ;
Fauconnier, A .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2001, 80 (04) :349-354
[9]   Gonadotropin-releasing hormone agonist treatment for endometriosis of the rectovaginal septum [J].
Fedele, L ;
Bianchi, S ;
Zanconato, G ;
Tozzi, L ;
Raffaelli, R .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2000, 183 (06) :1462-1467
[10]   Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis [J].
Fedele, L ;
Bianchi, S ;
Zanconato, G ;
Portuese, A ;
Raffaelli, R .
FERTILITY AND STERILITY, 2001, 75 (03) :485-488