Human T-lymphotropic Virus Type-I (HTLV-I)-associated Myelopathy with Bulbar Palsy-type Amyotrophic Lateral Sclerosis-like Symptoms

被引：6

作者：

Ando, Rina ^{[1
]}

Nishikawa, Noriko ^{[1
]}

Tsujii, Tomoaki ^{[1
]}

Iwaki, Hirotaka ^{[1
]}

Yabe, Hayato ^{[1
]}

Nagai, Masahiro ^{[1
]}

Nomoto, Masahiro ^{[1
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept Neurol & Clin Pharmacol, Matsuyama, Ehime 790, Japan

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 09期

关键词：

HTLV-I-associated myelopathy (HAM); bulbar palsy; amyotrophic lateral sclerosis (ALS); neopterin; anti-HTLV-I antibody; steroid therapy; SPASTIC PARAPARESIS; CEREBROSPINAL-FLUID; MANIFESTATIONS; INFECTION; NEOPTERIN;

D O I：

10.2169/internalmedicine.54.3660

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a case of Human T-lymphotropic virus type-I (HTLV-I)-associated myelopathy with bulbar palsy-type amyotrophic lateral sclerosis-like symptoms. A 52-year-old woman developed dyslalia at approximately 40 years of age, which slowly progressed. She presented with muscular atrophy and increased tendon reflexes of the extremities as well as bulbar palsy, from which motor neuron disease was suspected. Cerebrospinal fluid (CSF) testing revealed no abnormalities except for an elevated neopterin concentration at 143.17 pmol/mL (normal <= 30 pmol/mL). Her serum and CSF anti-HTLV-I antibody titers were also high. Intravenous infusions of methylprednisolone decreased the CSF neopterin concentration to 50.33 pmol/mL. Subsequent oral prednisolone therapy was effective in alleviating the symptoms.

引用

页码：1105 / 1107

页数：3

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