Synthesis, characterization, DNA binding and cleavage studies of mixed-ligand copper (II) complexes

被引：60

作者：

Sunita, M. ^{[1
]}

Anupama, B. ^{[1
]}

Ushaiah, B. ^{[1
]}

Kumari, C. Gyana ^{[1
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2017年 / 10卷

关键词：

Metal complexes; Fluorescence; Thermal melting; Viscosity; DNA cleavage; BENZIMIDAZOLE DERIVATIVES; ANTIMICROBIAL ACTIVITY; ANTICANCER ACTIVITY; CRYSTAL-STRUCTURES; RUTHENIUM(II); AGENTS; CYTOTOXICITY; FLUORESCENCE; MANGANESE(II); ANTIOXIDANT;

D O I：

10.1016/j.arabjc.2014.01.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New two copper complexes of type [Cu(Bzimpy)(L)H2O]SO4 (where L = 2,2' bipyridine (bpy), and ethylene diamine (en)), Bzimpy = 2,6-bis(benzimidazole-2yl) pyridine have been synthesized and characterized by elemental analyses, molar conductance measurements, magnetic susceptibility measurements, mass, IR, electronic and EPR spectral studies. Based on elemental and spectral studies six coordinated geometries were assigned to the two complexes. DNA-binding properties of these metal complexes were investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and thermal denaturation methods. Experimental studies suggest that the complexes bind to DNA through intercalation. These complexes also promote the cleavage of plasmid pBR322, in the presence of H2O2. (C) 2014 King Saud University. Production and hosting by Elsevier B.V.

引用

页码：S3367 / S3374

页数：8

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