Biflavonoids as novel antituberculosis agents

被引：67
作者：
Lin, YM [1 ]
Flavin, MT
Cassidy, CS
Mar, A
Chen, FC
机构：
[1] MediChem Life Sci, Woodridge, IL 60517 USA
[2] Natl Taiwan Univ, Dept Chem, Taipei 10764, Taiwan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 16期
关键词：
D O I：
10.1016/S0960-894X(01)00382-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of naturally occurring and synthetic biflavonoids was evaluated for inhibitory activity against Mycobacterium tuberculosis H37Rv (Mtb). Compounds 6, 24, and 25 demonstrated 96, 95, and 87% inhibition. respectively. at a screening concentration of 12.5 mug/mL. The type of linkage and the presence of methoxy- and vitro-substituents in biflavonoids may contribute to the observed inhibitory activity. The results of this study represent the discovery of biflavonoids as a potential new class of antituberculosis agent. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：2101 / 2104
页数：4
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