Biflavonoids as novel antituberculosis agents

被引：65
作者：
Lin, YM [1 ]
Flavin, MT
Cassidy, CS
Mar, A
Chen, FC
机构：
[1] MediChem Life Sci, Woodridge, IL 60517 USA
[2] Natl Taiwan Univ, Dept Chem, Taipei 10764, Taiwan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 16期
关键词：
D O I：
10.1016/S0960-894X(01)00382-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of naturally occurring and synthetic biflavonoids was evaluated for inhibitory activity against Mycobacterium tuberculosis H37Rv (Mtb). Compounds 6, 24, and 25 demonstrated 96, 95, and 87% inhibition. respectively. at a screening concentration of 12.5 mug/mL. The type of linkage and the presence of methoxy- and vitro-substituents in biflavonoids may contribute to the observed inhibitory activity. The results of this study represent the discovery of biflavonoids as a potential new class of antituberculosis agent. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：2101 / 2104
页数：4
相关论文
共 27 条
[1]  
[Anonymous], DIS CONTROL PRIORITI
[2]   SYNTHESIS OF HEXA-ORTHO-METHYL-6,6''-BINARINGENIN AND HEXA-ORTHO-METHYL-6,6''-BIAPIGENIN [J].
CHEN, F ;
LIN, Y ;
SHUE, Y ;
UENG, T .
HETEROCYCLES, 1975, 3 (07) :529-532
[3]   SUCCEDANEA FLAVANONE - NEW 6,6''-BINARINGENIN FROM RHUS-SUCCEDANEA [J].
CHEN, FC ;
LIN, YM .
PHYTOCHEMISTRY, 1975, 14 (07) :1644-1647
[4]   RHUSFLAVANONE, A NEW BIFLAVANONE FROM SEEDS OF WAX-TREE [J].
CHEN, FC ;
LIN, YM .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (01) :98-101
[5]  
CHEN FC, 1959, P CHEM SOC LONDON, P232
[6]  
CHEN FC, 1975, PHYTOCHEMISTRY, V14, P300
[7]  
CHEN FC, 1967, NUNG YEH HUA HSUEH H, V5, pA14
[8]  
CHEN FC, 1961, S PHYT HONG KONG, P166
[9]   Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium [J].
Collins, LA ;
Franzblau, SG .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1004-1009
[10]   Fluoroquinolone action against mycobacteria: Effects of C-8 substituents on growth, survival, and resistance [J].
Dong, YZ ;
Xu, C ;
Zhao, XL ;
Domagala, J ;
Drlica, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (11) :2978-2984
123