Fecal carriage of extended-spectrum and AmpC β-lactamase-producing Enterobacteriaceae in surgical patients before and after antibiotic prophylaxis

被引：4
作者：
Jakobsen, Lotte [1 ]
Kuhn, Katrin G. [1 ]
Hansen, Frank [1 ]
Skov, Robert L. [1 ]
Hammerum, Anette M. [1 ]
Littauer, Pia J. [2 ]
Thorlacius-Ussing, Ole [3 ,4 ]
Gebuhr, Peter H. [5 ]
Knudsen, Jenny D. [2 ]
Schonheyder, Henrik C. [4 ,6 ]
机构：
[1] Statens Serum Inst, Dept Microbiol & Infect Control, Copenhagen, Denmark
[2] Univ Copenhagen, Hvidovre Hosp, Dept Clin Microbiol, Hvidovre, Denmark
[3] Aalborg Univ Hosp, Dept Gastrointestinal Surg, Aalborg, Denmark
[4] Aalborg Univ, Dept Clin Med, Aalborg, Denmark
[5] Univ Copenhagen, Hvidovre Hosp, Dept Orthoped Surg, Hvidovre, Denmark
[6] Aalborg Univ Hosp, Dept Clin Microbiol, Aalborg, Denmark
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2016年 / 86卷 / 03期
关键词：
Beta-lactamases; ESBL; AmpC; Enterobacteriaceae; Antibiotic prophylaxis; Surgical procedures; Operative; Denmark; CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE; ESCHERICHIA-COLI; CTX-M; COMMUNITY; COLONIZATION; INFECTIONS; PREVALENCE; RESISTANCE; NATIONWIDE; EMERGENCE;
D O I：
10.1016/j.diagmicrobio.2016.07.028
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The impact of antibiotic prophylaxis on fecal carriage of ESBL-/AmpC-/carbapenemase-producing Enterobacteriaceae (CPE) was investigated. Patients admitted for elective surgery or diagnostic procedure in a Department of Surgical Gastroenterology (SG) (n=450) and Orthopedic Surgery (OS) (n=300) provided a fecal swab at admission and responded to a questionnaire on possible exposures. SG patients received gentamicin/penicillin G (+/- metronidazole); OS patients received cefuroxime. Two days after surgery a second swab was taken. From SG patients, 6% of first swabs and 9% of second swabs were positive for ESBL-/AmpC-producers. A similar carriage rate was observed in OS patients (6% and 8%, respectively). No CPE were detected. Escherichia coli was the predominant species and blaCTX-M-15 (29% and 22%) and blaCTX-M-14 (11% and 17%) were the most prevalent ESBL genotypes among SG and OS patients. Two different prophylactic antibiotic regimens had no impact on carriage rates. Previous hospitalization and antimicrobial treatment were associated with carriage for SG patients. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：316 / 321
页数：6
相关论文
共 28 条
  • [1] A New Clone Sweeps Clean: the Enigmatic Emergence of Escherichia coli Sequence Type 131
    Banerjee, Ritu
    Johnson, James R.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (09) : 4997 - 5004
  • [2] Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery
    Bratzler, Dale W.
    Dellinger, E. Patchen
    Olsen, Keith M.
    Perl, Trish M.
    Auwaerter, Paul G.
    Bolon, Maureen K.
    Fish, Douglas N.
    Napolitano, Lena M.
    Sawyer, Robert G.
    Slain, Douglas
    Steinberg, James P.
    Weinstein, Robert A.
    [J]. SURGICAL INFECTIONS, 2013, 14 (01) : 73 - 156
  • [3] THE TIMING OF PROPHYLACTIC ADMINISTRATION OF ANTIBIOTICS AND THE RISK OF SURGICAL-WOUND INFECTION
    CLASSEN, DC
    EVANS, RS
    PESTOTNIK, SL
    HORN, SD
    MENLOVE, RL
    BURKE, JP
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (05) : 281 - 286
  • [4] Extended-spectrum β-lactamase-producing organisms
    Falagas, M. E.
    Karageorgopoulos, D. E.
    [J]. JOURNAL OF HOSPITAL INFECTION, 2009, 73 (04) : 345 - 354
  • [5] Detection of CTX-M-64 in Escherichia coli Isolates from Human Patients in China
    Gu, Dan-xia
    Yu, Tao
    Wang, Yang
    Zhang, Rong
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (02) : 1371 - +
  • [6] The AmpC phenotype in Norwegian clinical isolates of Escherichia coli is associated with an acquired ISEcp1-like ampC element or hyperproduction of the endogenous AmpC
    Haldorsen, Bjorg
    Aasnaes, Bettina
    Dahl, Kristin H.
    Hanssen, Anne-Merethe
    Simonsen, Gunnar S.
    Walsh, Timothy R.
    Sundsfjord, Arnfinn
    Lundblad, Eirik W.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 62 (04) : 694 - 702
  • [7] Faecal carriage of extended-spectrum β-lactamase-producing and AmpC β-lactamase-producing bacteria among Danish army recruits
    Hammerum, A. M.
    Lester, C. H.
    Jakobsen, L.
    Porsbo, L. J.
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2011, 17 (04) : 566 - 568
  • [8] Hammerum AM, 2014, J ANTIMICROB CHEMOTH, P1
  • [9] Extended-spectrum β-lactamase (ESBL) in Danish clinical isolates of Escherichia coli and Klebsiella pneumoniae: Prevalence, β-lactamase distribution, phylogroups, and co-resistance
    Hansen, Dennis Schroder
    Schumacher, Helga
    Hansen, Frank
    Stegger, Marc
    Hertz, Frederik Boetius
    Schonning, Kristian
    Justesen, Ulrik Stenz
    Frimodt-Moller, Niels
    [J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2012, 44 (03) : 174 - 181
  • [10] Hansen F, 2014, MICROB DRUG RESIST, V67, P2049
123