Efficient, protection-free Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles

被引：13

作者：

Cousaert, N ^{[1
]}

Toto, P ^{[1
]}

Willand, N ^{[1
]}

Deprez, B ^{[1
]}

机构：

[1] Fac Sci Pharmaceut & Biol, UMR 8525, Lab Chim Gen & Chim Organ, F-59006 Lille, France

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 38期

关键词：

ortho-biphenyltetrazole; Suzuki-Miyaura cross-coupling; microwave synthesis;

D O I：

10.1016/j.tetlet.2005.07.082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe an efficient protocol for the Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles from non-protected 2-bromophenyltetrazole and arylboronic acids. The optimised conditions were achieved using [1, 1 '-bis(diphenylphosphino)ferrocene]dichloropalladium(II) as catalyst and Na2CO3 as base. A panel of structurally diverse arylboronic acids was used to demonstrate the scope of the coupling procedure. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6529 / 6532

页数：4

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