All-In-One Biomimetic Nanoplatform Based on Hollow Polydopamine Nanoparticles for Synergistically Enhanced Radiotherapy of Colon Cancer

被引:87
作者
Gong, Liuyun [1 ]
Zhang, Yujie [2 ,3 ]
Zhao, Jing [4 ]
Zhang, Yilei [2 ,3 ]
Tu, Kangsheng [5 ]
Jiao, Lianying [2 ,3 ]
Xu, Qiuran [6 ,7 ]
Zhang, Mingzhen [2 ,3 ]
Han, Suxia [1 ]
机构
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Radiotherapy, Xian 710061, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Sch Basic Med Sci, Xian Key Lab Immune Related Dis, Xian 710061, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, Minist Educ, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China
[4] Soochow Univ, Affiliated Hosp 1, Dept Radiotherapy, Suzhou 215000, Jiangsu, Peoples R China
[5] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Xian 710061, Shaanxi, Peoples R China
[6] Hangzhou Med Coll, Lab Tumor Mol Diag & Individualized Med Zhejiang, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China
[7] Res Ctr Diag & Treatment Technol Hepatocellular C, Hangzhou 310009, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
biomimetic nanoplatforms; hypoxia; purine metabolism pathway; radiosensitizers; X-ray induced photodynamic therapies; MEMBRANE-CAMOUFLAGED NANOPARTICLES; INDUCED PHOTODYNAMIC THERAPY; DRUG-DELIVERY SYSTEM; X-RAY; DSB REPAIR; HOMOLOGOUS RECOMBINATION; APOPTOSIS; HYPOXIA; APOPTIN; RADIOSENSITIZERS;
D O I
10.1002/smll.202107656
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Even though radiotherapy is the most important therapeutic strategy for colon cancer treatment, there is an enormous demand to improve radiosensitivity in solid tumor destruction. For this purpose, a biomimetic nanoplatform based on hollow polydopamine nanoparticles (HP) with homologous targeting and pH-responsive drug release properties is designed. In this work, HP is constructed by using a chelation competition-induced polymerization strategy and then modified with the cancer cell membrane. Hollow polydopamine integrated with Pt nanoparticles (Pt@HP) has a catalase-like activity, which can be used to trigger endogenous H2O2 into O-2, relieving hypoxia of the tumor microenvironment (TME). With mesoporous shells and large cavities, Pt@HP shows efficient apoptin(100-109) (AP) and verteporfin (VP) loading to form AVPt@HP@M. Under X-ray irradiation, AVPt@HP@M exerts a radiosensitization effect via multiple strategies, including relieving hypoxia (Pt NPs), enhancing tumor apoptosis (AP), and X-ray-induced photodynamic therapy (X-PDT) (VP). Further metabonomics analysis shows that the specific mechanism of the AVPt@HP@M is through influencing purine metabolism. Without appreciable systemic toxicity, this nanoplatform highlights a new strategy for effective radiosensitization and provides a reference for treating malignant tumors.
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页数:16
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