A Novel Constrained Non-negative Matrix Factorization Method for Group Functional Magnetic Resonance Imaging Data Analysis of Adult Attention-Deficit/Hyperactivity Disorder

被引:2
作者
Li, Ying [1 ]
Zeng, Weiming [1 ]
Shi, Yuhu [1 ]
Deng, Jin [2 ]
Nie, Weifang [1 ]
Luo, Sizhe [1 ]
Yang, Jiajun [3 ]
机构
[1] Shanghai Maritime Univ, Lab Digital Image & Intelligent Computat, Shanghai, Peoples R China
[2] South China Agr Univ, Coll Math & Informat, Guangzhou, Peoples R China
[3] Shanghai Jiao Tong Univ, Dept Neurol, Affiliated Peoples Hosp 6, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
attention deficit hyperactivity disorder; constrained non-negative matrix factorization; dynamic functional connectivity; functional magnetic resonance imaging; intrinsic reference; INDEPENDENT COMPONENT ANALYSIS; CONNECTIVITY; ARCHITECTURE; DYSCONNECTIVITY; DECOMPOSITION; INFERENCES; DEFAULT; STATES; MRI; ICA;
D O I
10.3389/fnins.2022.756938
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Attention-deficit/hyperactivity disorder (ADHD) is a common childhood psychiatric disorder that often persists into adulthood. Extracting brain networks from functional magnetic resonance imaging (fMRI) data can help explore neurocognitive disorders in adult ADHD. However, there is still a lack of effective methods to extract large-scale brain networks to identify disease-related brain network changes. Hence, this study proposed a spatial constrained non-negative matrix factorization (SCNMF) method based on the fMRI real reference signal. First, non-negative matrix factorization analysis was carried out on each subject to select the brain network components of interest. Subsequently, the available spatial prior information was mined by integrating the interested components of all subjects. This prior constraint was then incorporated into the NMF objective function to improve its efficiency. For the sake of verifying the effectiveness and feasibility of the proposed method, we quantitatively compared the SCNMF method with other classical algorithms and applied it to the dynamic functional connectivity analysis framework. The algorithm successfully extracted ten resting-state brain functional networks from fMRI data of adult ADHD and healthy controls and found large-scale brain network changes in adult ADHD patients, such as enhanced connectivity between executive control network and right frontoparietal network. In addition, we found that older ADHD spent more time in the pattern of relatively weak connectivity. These findings indicate that the method can effectively extract large-scale functional networks and provide new insights into understanding the neurobiological mechanisms of adult ADHD from the perspective of brain networks.
引用
收藏
页数:13
相关论文
共 48 条
[1]   Tracking Whole-Brain Connectivity Dynamics in the Resting State [J].
Allen, Elena A. ;
Damaraju, Eswar ;
Plis, Sergey M. ;
Erhardt, Erik B. ;
Eichele, Tom ;
Calhoun, Vince D. .
CEREBRAL CORTEX, 2014, 24 (03) :663-676
[2]   A baseline for the multivariate comparison of resting-state networks [J].
Allen, Elena A. ;
Erhardt, Erik B. ;
Damaraju, Eswar ;
Gruner, William ;
Segall, Judith M. ;
Silva, Rogers F. ;
Havlicek, Martin ;
Rachakonda, Srinivas ;
Fries, Jill ;
Kalyanam, Ravi ;
Michael, Andrew M. ;
Caprihan, Arvind ;
Turner, Jessica A. ;
Eichele, Tom ;
Adelsheim, Steven ;
Bryan, Angela D. ;
Bustillo, Juan ;
Clark, Vincent P. ;
Ewing, Sarah W. Feldstein ;
Filbey, Francesca ;
Ford, Corey C. ;
Hutchison, Kent ;
Jung, Rex E. ;
Kiehl, Kent A. ;
Kodituwakku, Piyadasa ;
Komesu, Yuko M. ;
Mayer, Andrew R. ;
Pearlson, Godfrey D. ;
Phillips, John P. ;
Sadek, Joseph R. ;
Stevens, Michael ;
Teuscher, Ursina ;
Thoma, Robert J. ;
Calhoun, Vince D. .
FRONTIERS IN SYSTEMS NEUROSCIENCE, 2011, 5
[3]  
Beckmann C. F., 2009, Neuroimage, V47, pS148, DOI [10.1016/S1053-8119(09)71511-3, DOI 10.1016/S1053-8119(09)71511-3]
[4]   Tensorial extensions of independent component analysis for multisubject FMRI analysis [J].
Beckmann, CF ;
Smith, SM .
NEUROIMAGE, 2005, 25 (01) :294-311
[5]   The modular and integrative functional architecture of the human brain [J].
Bertolero, Maxwell A. ;
Yeo, B. T. Thomas ;
D'Esposito, Mark .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (49) :E6798-E6807
[6]   Psychopathology and the Human Connectome: Toward a Transdiagnostic Model of Risk For Mental Illness [J].
Buckholtz, Joshua W. ;
Meyer-Lindenberg, Andreas .
NEURON, 2012, 74 (06) :990-1004
[7]   Attention-Deficit/Hyperactivity Disorder and Attention Networks [J].
Bush, George .
NEUROPSYCHOPHARMACOLOGY, 2010, 35 (01) :278-300
[8]  
Calhoun V.D., 2003, ICA of functional MRI data: an overview
[9]   A method for making group inferences from functional MRI data using independent component analysis [J].
Calhoun, VD ;
Adali, T ;
Pearlson, GD ;
Pekar, JJ .
HUMAN BRAIN MAPPING, 2001, 14 (03) :140-151
[10]   The Chronnectome: Time-Varying Connectivity Networks as the Next Frontier in fMRI Data Discovery [J].
Calhoun, Vince D. ;
Miller, Robyn ;
Pearlson, Godfrey ;
Adali, Tulay .
NEURON, 2014, 84 (02) :262-274