Strategies of Explanatory Abstraction in Molecular Systems Biology

被引：0
|
作者：
Jones, Nicholaos [1 ]
机构：
[1] Univ Alabama, Dept Philosophy, 332 Morton Hall,301 Sparkman Dr, Huntsville, AL 35899 USA
来源：
PHILOSOPHY OF SCIENCE | 2018年 / 85卷 / 05期
关键词：
ADAPTATION;
D O I：
暂无
中图分类号：
N09 [自然科学史]; B [哲学、宗教];
学科分类号：
01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;
摘要：
I consider three explanatory strategies from recent systems biology that are driven by mathematics as much as mechanistic detail. Analysis of differential equations drives the first strategy; topological analysis of network motifs drives the second; mathematical theorems from control engineering drive the third. I also distinguish three abstraction types: aggregations, which simplify by condensing details; generalizations, which simplify by generalizing details; and structurations, which simplify by contextualizing details. Using a common explanandum as a reference pointnamely, the robust perfect adaptation of chemotaxis in Escherichia coliI argue that each strategy targets various abstraction types to different mechanistic details.
引用
收藏
页码：955 / 968
页数：14
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