UVA-induced damage to DNA and proteins: direct versus indirect photochemical processes

被引：54
|
作者：
Girard, P. M. [1 ,2 ,3 ]
Francesconi, S. [1 ,2 ,3 ]
Pozzebon, M. [1 ,2 ,3 ]
Graindorge, D. [1 ,2 ,3 ]
Rochette, P. [4 ]
Drouin, R. [5 ]
Sage, E. [1 ,2 ,3 ]
机构：
[1] Ctr Univ Orsay, Inst Curie, Bat 110, F-91405 Orsay, France
[2] Ctr Univ, CNRS, UMR 3348, F-91405 Orsay, France
[3] Univ Paris Sud 11, F-91405 Orsay, France
[4] Univ Laval, Ctr Rech FRSQ, Ctr Hosp Affilie Univ Quebec, Quebec City, PQ, Canada
[5] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Pediat, Div Genet, Quebec City, PQ, Canada
来源：
COST CHEMISTRY CM0603-MELUSYN JOINT MEETING: DAMAGES INDUCED IN BIOMOLECULES BY LOW AND HIGH ENERGY RADIATIONS | 2011年 / 261卷
关键词：
CYCLOBUTANE PYRIMIDINE DIMERS; OXYGEN-MEDIATED DAMAGE; HUMAN SKIN FIBROBLASTS; SINGLET OXYGEN; 365; NM; BIPYRIMIDINE PHOTOPRODUCTS; ULTRAVIOLET-RADIATION; WAVELENGTH DEPENDENCE; STRAND BREAKS; INDUCTION;
D O I：
10.1088/1742-6596/261/1/012002
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
UVA has long been known for generating an oxidative stress in cells. In this paper we review the different types of DNA damage induced by UVA, i.e. strand breaks, bipyrimidine photoproducts, and oxidatively damaged bases. Emphasis is given to the mechanism of formation that is further illustrated by the presentation of new in vitro data. Examples of oxidation of proteins involved in DNA metabolism are also given.
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页数：10
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