Near-Infrared Mitochondria-Targetable Single-Molecule probe for Dual-Response of viscosity and sulfur dioxide in vivo

被引：14

作者：

Zhang, Guihua ^{[1
]}

Quan, Wei ^{[1
]}

Li, Yanxia ^{[1
]}

Song, Wenhui ^{[1
]}

Lin, Weiying ^{[1
]}

机构：

[1] Guangxi Univ, Sch Chem & Chem Engn, Inst Opt Mat & Chem Biol, Guangxi Key Lab Electrochem Energy Mat, Nanning 530004, Guangxi, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2022年 / 270卷

基金：

中国国家自然科学基金;

关键词：

Near-infrared fluorescent probe; In vivo imaging; Dual-response; Viscosity; Sulfur dioxide; RATIOMETRIC FLUORESCENT-PROBE; SO2; DERIVATIVES; 2-PHOTON; MECHANISMS; DIAGNOSIS;

D O I：

10.1016/j.saa.2021.120796

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Studies have demonstrated that the viscosity and SO2 in mitochondria are involved in various physiological processes, which are both important for maintaining the normal function of mitochondria. In this research, we rationally designed and synthesized a novel mitochondria-targetable fluorescent probe Mito-MG with near-infrared absorption and emission for dual-response of viscosity and SO2. Based on the TICT mechanism and Michael addition reaction, the probe Mito-MG responds to viscosity and SO2 with different near-infrared fluorescence signals. Importantly, Mito-MG presented outstanding mitochondrial targeting ability (Pearson's colocalization coefficient is 0.8602) and has been successfully applied to imaging of the cells, zebrafish and mice. We believe that Mito-MG could be applied as a powerful tool for a deep understanding of the connection of viscosity and SO2 in biological systems. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：8

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