Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9

被引：66

作者：

Buggins, Andrea G. S. ^{[1
]}

Levi, Ana

Gohil, Satyen

Fishlock, Keith ^{[2
]}

Patten, Piers E. M.

Calle, Yolanda

Yallop, Deborah

Devereux, Stephen

机构：

[1] Kings Coll London, Rayne Inst, Dept Haematol Med, London SE5 9NU, England

[2] Kings Coll Hosp NHS Fdn Trust, London, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2011年 / 154卷 / 02期

关键词：

chronic lymphocytic leukaemia; CD38; CD49d; CD44; matrix metalloproteinase-9; CHRONIC LYMPHOCYTIC-LEUKEMIA; B-CELLS; EXPRESSION; SURVIVAL; ACTIVATION; MIGRATION; INTEGRIN; ZAP-70;

D O I：

10.1111/j.1365-2141.2011.08725.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Progressive chronic lymphocytic leukaemia is characterized by the accumulation of neoplastic B-cells in the tissues and correlates with the expression of prognostic biomarkers, such as CD38, CD49d and matrix metalloproteinase-9 (MMP9), which are involved in migration and tissue invasion. In this study we investigated the physical relationship between these molecules and demonstrated that CD38, CD49d, MMP9 and CD44 were physically associated in a supramolecular cell surface complex. Our findings provide a molecular basis for the correlation between expression of these proteins and prognosis and, as the complex is not present in normal B-cells, suggest a novel leukaemia-specific therapeutic target.

引用

页码：216 / 222

页数：7

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