Determination of Hormone Antagonists in Waste-Water Samples by Micellar Electrokinetic Chromatography

被引：3

作者：

Rucins, Martins ^{[1
,2
]}

Baron, Daniel ^{[1
]}

Plotniece, Aiva ^{[2
]}

Petr, Jan ^{[1
]}

机构：

[1] Palacky Univ Olomouc, Reg Ctr Adv Technol & Mat, Dept Analyt Chem, 17 Listopadu 12, Olomouc 77146, Czech Republic

[2] Latvian Inst Organ Synth, Aizkraukles Str 21, LV-1006 Riga, Latvia

来源：

CHROMATOGRAPHIA | 2018年 / 81卷 / 12期

关键词：

Endocrine disruptors; Micellar electrokinetic chromatography; Waste-water; ENDOCRINE-DISRUPTING COMPOUNDS; PERSONAL CARE PRODUCTS; CAPILLARY-ELECTROPHORESIS; PHARMACEUTICALS; ESTROGENS;

D O I：

10.1007/s10337-018-3631-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The contamination of water represents a major problem in many parts of the world. Endocrine disrupting compounds belong to the water contaminants and affect, besides other things, hormonal equilibrium in the living organisms. Such compounds are of different chemical structures and there is a demand for their fast determination in water samples. In our work, we focused on the development of a simple and fast method for separation and determination of five model hormone antagonists, exemestane, toremifene, letrozole, anastrozole, and mifepristone, by micellar electrokinetic chromatography. Within the best conditions, 50mM sodium borate pH 9.5, 50mM SDS, 15% 1-propanol, 20kV, the separation of all the compounds lasted 8min. The method was successfully validated with LODs of 1.2-7.7 mu gmL(-1), LOQs of 4.0-25.6 mu gmL(-1) and intraday repeatability of peak areas of 0.8-1.1%. Moreover, it was applied to the analysis of spiked water samples from a local waste-water treatment plant using SPE as a pretreatment step.

引用

页码：1607 / 1612

页数：6

共 24 条

[11] Methodology for profiling anti-androgen mixtures in river water using multiple passive samplers and bioassay-directed analyses [J].

Liscio, Camilla ;

Abdul-Sada, Alaa ;

Al-Salhi, Raghad ;

Ramsey, Michael H. ;

Hill, Elizabeth M. .

WATER RESEARCH, 2014, 57 :258-269

[12] Determination of a broad spectrum of endocrine-disrupting pesticides in fish samples by UHPLC-MS/MS using the pass-through cleanup approach [J].

Liu, Shaoying ;

Huang, Xihui ;

Jin, Quan ;

Zhu, Guonian .

JOURNAL OF SEPARATION SCIENCE, 2017, 40 (06) :1266-1272

[13] Analysis of hormone antagonists in clinical and municipal wastewater by isotopic dilution liquid chromatography tandem mass spectrometry [J].

Liu, Xianjun ;

Zhang, Jing ;

Yin, Jie ;

Duan, Hejun ;

Wu, Yongning ;

Shao, Bing .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 396 (08) :2977-2985

[14] Occurrence, fate and removal of synthetic oral contraceptives (SOCs) in the natural environment: A review [J].

Liu, Ze-hua ;

Ogejo, Jactone Arogo ;

Pruden, Amy ;

Knowlton, Katharine F. .

SCIENCE OF THE TOTAL ENVIRONMENT, 2011, 409 (24) :5149-5161

[15] Determination of nonylphenol and nonylphenol ethoxylates in wastewater using MEKC [J].

Nunez, Laura ;

Wiedmer, Susanne K. ;

Parshintsev, Jevgeni ;

Hartonen, Kari ;

Riekkola, Marja-Liisa ;

Tadeo, Jose L. ;

Turiel, Esther .

JOURNAL OF SEPARATION SCIENCE, 2009, 32 (12) :2109-2116

[16] Endocrine disrupting compounds (EDCs) in environmental matrices: Review of analytical strategies for pharmaceuticals, estrogenic hormones, and alkylphenol compounds [J].

Omar, Tuan Fauzan Tuan ;

Ahmad, Azrilawani ;

Aris, Ahmad Zaharin ;

Yusoff, Fatimah Md .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2016, 85 :241-259

[17] Novel modes of capillary electrophoresis for the determination of endocrine disrupting chemicals [J].

Regan, F ;

Moran, A ;

Fogarty, B ;

Dempsey, E .

JOURNAL OF CHROMATOGRAPHY A, 2003, 1014 (1-2) :141-152

[18] Bioassay-Directed Identification of Novel Antiandrogenic Compounds in Bile of Fish Exposed to Wastewater Effluents [J].

Rostkowski, Pawel ;

Horwood, Julia ;

Shears, Janice A. ;

Lange, Anke ;

Oladapo, Francis O. ;

Besselink, Harrie T. ;

Tyler, Charles R. ;

Hill, Elizabeth M. .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2011, 45 (24) :10660-10667

[19]

Salvia M. V., 2014, PHARM ANAL ACTA, V5, P1

[20] Determination of estrogens in sludge and sediments by liquid extraction and GC/MS/MS [J].

Ternes, TA ;

Andersen, H ;

Gilberg, D ;

Bonerz, M .

ANALYTICAL CHEMISTRY, 2002, 74 (14) :3498-3504

← 1 2 3 →