共 66 条
CaMKII-δ9 Induces Cardiomyocyte Death to Promote Cardiomyopathy and Heart Failure
被引:4
作者:

Zhang, Mao
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China
Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China

Zhang, Junxia
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China

Zhang, Wenjia
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Sch Basic Med Sci,Inst Cardiovasc Sci,Minist Educ, Beijing, Peoples R China Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China

Hu, Qingmei
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China

Jin, Li
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China

Xie, Peng
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China

Zheng, Wen
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China

Shang, Haibao
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China

Zhang, Yan
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China
Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Sch Basic Med Sci,Inst Cardiovasc Sci,Minist Educ, Beijing, Peoples R China
Beijing Key Lab Cardiovasc Receptors Res, Beijing, Peoples R China Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China
机构:
[1] Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing, Peoples R China
[2] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA
[3] Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Sch Basic Med Sci,Inst Cardiovasc Sci,Minist Educ, Beijing, Peoples R China
[4] Beijing Key Lab Cardiovasc Receptors Res, Beijing, Peoples R China
基金:
国家重点研发计划;
中国国家自然科学基金;
关键词:
CaMKII;
CaMKII-delta;
9;
cardiomyocyte death;
cardiomyopathy;
heart failure;
hypertrophy;
PROTEIN-KINASE-II;
CARDIAC-HYPERTROPHY;
MYOCARDIAL ISCHEMIA/REPERFUSION;
INHIBITION PROTECTS;
CELL-DEATH;
INDEPENDENT ACTIVATION;
OXIDATIVE ACTIVATION;
CAMKII INHIBITION;
ER STRESS;
DELTA-B;
D O I:
10.3389/fcvm.2021.820416
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Heart failure is a syndrome in which the heart cannot pump enough blood to meet the body's needs, resulting from impaired ventricular filling or ejection of blood. Heart failure is still a global public health problem and remains a substantial unmet medical need. Therefore, it is crucial to identify new therapeutic targets for heart failure. Ca2+/calmodulin-dependent kinase II (CaMKII) is a serine/threonine protein kinase that modulates various cardiac diseases. CaMKII-delta 9 is the most abundant CaMKII-delta splice variant in the human heart and acts as a central mediator of DNA damage and cell death in cardiomyocytes. Here, we proved that CaMKII-delta 9 mediated cardiomyocyte death promotes cardiomyopathy and heart failure. However, CaMKII-delta 9 did not directly regulate cardiac hypertrophy. Furthermore, we also showed that CaMKII-delta 9 induced cell death in adult cardiomyocytes through impairing the UBE2T/DNA repair signaling. Finally, we demonstrated no gender difference in the expression of CaMKII-delta 9 in the hearts, together with its related cardiac pathology. These findings deepen our understanding of the role of CaMKII-delta 9 in cardiac pathology and provide new insights into the mechanisms and therapy of heart failure.
引用
收藏
页数:11
相关论文
共 66 条
[1]
RESPONSE OF FAILING CANINE AND HUMAN HEART-CELLS TO BETA(2)-ADRENERGIC STIMULATION
[J].
ALTSCHULD, RA
;
STARLING, RC
;
HAMLIN, RL
;
BILLMAN, GE
;
HENSLEY, J
;
CASTILLO, L
;
FERTEL, RH
;
HOHL, CM
;
ROBITAILLE, PML
;
JONES, LR
;
XIAO, RP
;
LAKATTA, EG
.
CIRCULATION,
1995, 92 (06)
:1612-1618

ALTSCHULD, RA
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

STARLING, RC
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

HAMLIN, RL
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

BILLMAN, GE
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

HENSLEY, J
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

CASTILLO, L
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

FERTEL, RH
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

HOHL, CM
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

ROBITAILLE, PML
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

JONES, LR
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

XIAO, RP
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210

LAKATTA, EG
论文数: 0 引用数: 0
h-index: 0
机构: OHIO STATE UNIV,DEPT PHYSIOL,COLUMBUS,OH 43210
[2]
The Global Health and Economic Burden of Hospitalizations for Heart Failure Lessons Learned From Hospitalized Heart Failure Registries
[J].
Ambrosy, Andrew P.
;
Fonarow, Gregg C.
;
Butler, Javed
;
Chioncel, Ovidiu
;
Greene, Stephen J.
;
Vaduganathan, Muthiah
;
Nodari, Savina
;
Lam, Carolyn S. P.
;
Sato, Naoki
;
Shah, Ami N.
;
Gheorghiade, Mihai
.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,
2014, 63 (12)
:1123-1133

Ambrosy, Andrew P.
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA

Fonarow, Gregg C.
论文数: 0 引用数: 0
h-index: 0
机构:
Ronald Reagan UCLA Med Ctr, Ahmanson UCLA Cardiomyopathy Ctr, Los Angeles, CA USA Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA

Butler, Javed
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Div Cardiol, Atlanta, GA 30322 USA Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA

Chioncel, Ovidiu
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Emergency Cardiovasc Dis Prof CC Iliescu, Bucharest, Romania Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA

Greene, Stephen J.
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Ctr Cardiovasc Innovat, Feinberg Sch Med, Chicago, IL 60601 USA Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA

论文数: 引用数:
h-index:
机构:

Nodari, Savina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Brescia, Dept Cardiol, Brescia, Italy Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA

Lam, Carolyn S. P.
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Univ Hlth Ctr, Singapore, Singapore Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA

Sato, Naoki
论文数: 0 引用数: 0
h-index: 0
机构:
Musashi Kosugi Hosp, Nippon Med Sch, Kawasaki, Kanagawa, Japan Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA

Shah, Ami N.
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Ctr Cardiovasc Innovat, Feinberg Sch Med, Chicago, IL 60601 USA Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA

Gheorghiade, Mihai
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Ctr Cardiovasc Innovat, Feinberg Sch Med, Chicago, IL 60601 USA Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA
[3]
CaMKII in myocardial hypertrophy and heart failure
[J].
Anderson, Mark E.
;
Brown, Joan Heller
;
Bers, Donald M.
.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,
2011, 51 (04)
:468-473

Anderson, Mark E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Univ Iowa, Dept Mol Physiol & Biophsy, Carver Coll Med, Iowa City, IA 52242 USA Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA

Brown, Joan Heller
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA

Bers, Donald M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Davis, Dept Pharmacol, Davis, CA 95616 USA Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
[4]
RETRACTED: Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy (Publication with Expression of Concern. See vol. 50, pg. 9600, 2022) (Retracted Article)
[J].
Awad, Salma
;
Kunhi, Muhammad
;
Little, Gillian H.
;
Bai, Yan
;
An, Woojin
;
Bers, Donald
;
Kedes, Larry
;
Poizat, Coralie
.
NUCLEIC ACIDS RESEARCH,
2013, 41 (16)
:7656-7672

Awad, Salma
论文数: 0 引用数: 0
h-index: 0
机构:
King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia

Kunhi, Muhammad
论文数: 0 引用数: 0
h-index: 0
机构:
King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia

Little, Gillian H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ So Calif, Inst Genet Med, Los Angeles, CA 90033 USA King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia

Bai, Yan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ So Calif, Inst Genet Med, Los Angeles, CA 90033 USA King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia

An, Woojin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ So Calif, Dept Biochem & Mol Biol, Los Angeles, CA 90089 USA King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia

Bers, Donald
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Davis, Dept Pharmacol, Davis, CA 95616 USA King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia

Kedes, Larry
论文数: 0 引用数: 0
h-index: 0
机构:
Univ So Calif, Inst Genet Med, Los Angeles, CA 90033 USA King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia

Poizat, Coralie
论文数: 0 引用数: 0
h-index: 0
机构:
King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia
San Diego State Univ, Dept Biol, San Diego, CA 92182 USA King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia
[5]
CaM kinase II selectively signals to histone deacetylase 4 during cardiornyocyte hypertrophy
[J].
Backs, Johannes
;
Song, Kunhua
;
Bezprozvannaya, Svetlana
;
Chang, Shurong
;
Olson, Eric N.
.
JOURNAL OF CLINICAL INVESTIGATION,
2006, 116 (07)
:1853-1864

Backs, Johannes
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

Song, Kunhua
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

Bezprozvannaya, Svetlana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

Chang, Shurong
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

Olson, Eric N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
[6]
Ca2+/calmodulin-dependent protein kinase II is essential in hyperacute pressure overload
[J].
Baier, Maria J.
;
Klatt, Susanne
;
Hammer, Karin P.
;
Maier, Lars S.
;
Rokita, Adam G.
.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,
2020, 138
:212-221

Baier, Maria J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany

Klatt, Susanne
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany

Hammer, Karin P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany

Maier, Lars S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany

Rokita, Adam G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany
[7]
Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy
[J].
Beauverger, Philippe
;
Ozoux, Marie-Laure
;
Begis, Guillaume
;
Glenat, Valerie
;
Briand, Veronique
;
Philippo, Marie-Claire
;
Daveu, Cyril
;
Tavares, Georges
;
Roy, Sebastien
;
Corbier, Alain
;
Briand, Pascale
;
Dorchies, Olivier
;
Bauchet, Anne-Laure
;
Nicolai, Eric
;
Duclos, Olivier
;
Tamarelle, Dorothee
;
Pruniaux, Marie-Pierre
;
Muslin, Anthony J.
;
Janiak, Philip
.
CARDIOVASCULAR RESEARCH,
2020, 116 (02)
:329-338

Beauverger, Philippe
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Ozoux, Marie-Laure
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Begis, Guillaume
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Integrated Drug Discovery Platform, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Glenat, Valerie
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Integrated Drug Discovery Platform, 13 Quai Jules Guesde, F-94403 Vitry Sur Seine, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Briand, Veronique
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Philippo, Marie-Claire
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Daveu, Cyril
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Tavares, Georges
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Roy, Sebastien
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Integrated Drug Discovery Platform, 13 Quai Jules Guesde, F-94403 Vitry Sur Seine, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Corbier, Alain
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Briand, Pascale
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Dorchies, Olivier
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Preclin Safety Platform, 13 Quai Jules Guesde, F-94403 Vitry Sur Seine, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Bauchet, Anne-Laure
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Translat Med & Early Dev Platform, 13 Quai Jules Guesde, F-94403 Vitry Sur Seine, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Nicolai, Eric
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Integrated Drug Discovery Platform, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Duclos, Olivier
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Integrated Drug Discovery Platform, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Tamarelle, Dorothee
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Biostat & Programming Platform, 13 Quai Jules Guesde, F-94403 Vitry Sur Seine, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Pruniaux, Marie-Pierre
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Muslin, Anthony J.
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 640 Mem Dr, Cambridge, MA 02139 USA Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France

Janiak, Philip
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France Sanofi R&D, Cardiovasc & Metab Therapeut Area, 1 Ave Pierre Brossolette, F-91385 Chilly Mazarin, France
[8]
Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart
[J].
Bell, James R.
;
Raaijmakers, Antonia J. A.
;
Curl, Claire L.
;
Reichelt, Melissa E.
;
Harding, TristanW.
;
Bei, Aier
;
Ng, Dominic C. H.
;
Erickson, Jeffrey R.
;
Petroff, Martin Vila
;
Harrap, Stephen B.
;
Delbridge, Lea M. D.
.
INTERNATIONAL JOURNAL OF CARDIOLOGY,
2015, 181
:288-296

Bell, James R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

Raaijmakers, Antonia J. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

Curl, Claire L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

Reichelt, Melissa E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

Harding, TristanW.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

Bei, Aier
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

Ng, Dominic C. H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Dept Biochem & Mol Biol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

Erickson, Jeffrey R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Otago, Dept Physiol, Dunedin, New Zealand Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

Petroff, Martin Vila
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nacl La Plata, Fac Ciencias Med, Conicet La Plata, Ctr Invest Cardiovasc, RA-1900 La Plata, Buenos Aires, Argentina Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

Harrap, Stephen B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

Delbridge, Lea M. D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia
[9]
Heart Failure-Associated Hospitalizations in the United States
[J].
Blecker, Saul
;
Paul, Margaret
;
Taksler, Glen
;
Ogedegbe, Gbenga
;
Katz, Stuart
.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,
2013, 61 (12)
:1259-1267

Blecker, Saul
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA
NYU, Sch Med, Div Gen Internal Med, New York, NY 10016 USA NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA

Paul, Margaret
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA

Taksler, Glen
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA
NYU, Sch Med, Div Gen Internal Med, New York, NY 10016 USA NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA

Ogedegbe, Gbenga
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA
NYU, Sch Med, Div Gen Internal Med, New York, NY 10016 USA NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA

Katz, Stuart
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Div Cardiol, New York, NY 10016 USA NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA
[10]
CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis
[J].
Bracken, Christina
;
Beauverger, Philippe
;
Duclos, Olivier
;
Russo, Ryan J.
;
Rogers, Kelly A.
;
Husson, Herve
;
Natoli, Thomas A.
;
Ledbetter, Steven R.
;
Janiak, Philip
;
Ibraghimov-Beskrovnaya, Oxana
;
Bukanov, Nikolay O.
.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY,
2016, 310 (11)
:F1414-F1422

Bracken, Christina
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA

Beauverger, Philippe
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi, Cardiovasc Res, Chilly Mazarin, France Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA

Duclos, Olivier
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi, Cardiovasc Res, Chilly Mazarin, France Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA

Russo, Ryan J.
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA

Rogers, Kelly A.
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA

Husson, Herve
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA

Natoli, Thomas A.
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA

Ledbetter, Steven R.
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA

Janiak, Philip
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi, Cardiovasc Res, Chilly Mazarin, France Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA

Ibraghimov-Beskrovnaya, Oxana
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA

Bukanov, Nikolay O.
论文数: 0 引用数: 0
h-index: 0
机构:
Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA Sanofi Genzyme R&D Ctr, Rare Dis, Framingham, MA USA