A compact solvent extraction based 99Mo/99 mTc generator for hospital radiopharmacy

被引：6

作者：

Chattopadhyay, Sankha ^{[1
]}

Das, Sujata Saha ^{[1
]}

Barua, Luna ^{[1
]}

Pal, Asit Kumar ^{[1
]}

Kumar, Umesh ^{[1
]}

Madhusmita ^{[1
]}

Alam, Md Nayer ^{[1
]}

Hudait, Arup Kumar ^{[1
]}

Banerjee, Sharmila ^{[2
]}

机构：

[1] VECC, Radiopharmaceut Lab, Reg Ctr, BRIT, 1-AF, Kolkata 700064, India

[2] BARC, Radiat Med Ctr, Bombay 400012, Maharashtra, India

来源：

APPLIED RADIATION AND ISOTOPES | 2019年 / 143卷

关键词：

Compact Mo-99/Tc-99m generator; LSA Mo-99; Methyl Ethyl Ketone; Mechanical valve; Purification; Solvent Extraction; Tc-99m elution efficiency; CYCLOTRON PRODUCTION; TC-99M; SEPARATION; MO-99/TC-99M; MODULE; ACCELERATOR; TARGETS; COLUMN;

D O I：

10.1016/j.apradiso.2018.10.017

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A compact and portable Mo-99-Tc-99m generator based on solvent-extraction, mimic to the conventional Mo-99-Tc-99m alumina column generator is much-needed commodity for use in hospital radiopharmacy setup. The present study includes the development of a portable, simple and low cost Mo-99/Tc-99m-generator based on MEK solvent extraction technique to obtain a very high concentration of no-carrier added (nca) Tc-99m solution, where low specific activity Mo-99 source is obtained through Mo-98(n, gamma)Mo-99 reaction in a research reactor. The unit is intended for operation under the conditions of medical radiological laboratories. Technical trials showed that the mean time of preparation of sodium [Tc-99m] pertechnetate radiopharmaceutical did not exceed 15 min. The quality and yield of Tc-99m-pertechnetate is upto the mark for formulation of radiopharmaceuticals.

引用

页码：41 / 46

页数：6

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