Facile and general synthesis of quaternary 3-aminooxindoles

被引：103
作者：
Marsden, Stephen P. [1 ]
Watson, Emma L. [1 ]
Raw, Steven A. [2 ]
机构：
[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
[2] AstraZeneca Proc R&D, Macclesfield SK10 2NA, Cheshire, England
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 13期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1021/ol801028e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel approach to the valuable quaternary 3-aminooxindole skeleton is reported on the basis of intramolecular arylation of enolates of substituted amino acids. The reaction tolerates dialkyl- and arylalkylamines as well as a range of carbon substituents (primary and secondary alkyl, aryl). The cyclization of N-indolyl-substituted substrates is accompanied by direct C-H arylation of the indole, leading to indolo-fused benzodiazepines.
引用
收藏
页码：2905 / 2908
页数：4
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