The mammalian synaptonemal complex: Protein components, assembly and role in meiotic recombination

被引：124
作者：
Fraune, Johanna [1 ]
Schramm, Sabine [1 ]
Alsheimer, Manfred [1 ]
Benavente, Ricardo [1 ]
机构：
[1] Univ Wurzburg, Dept Cell & Dev Biol, Bioctr, D-97074 Wurzburg, Germany
来源：
EXPERIMENTAL CELL RESEARCH | 2012年 / 318卷 / 12期
关键词：
Meiosis; Synaptonemal complex; Mammals; MEIOSIS-SPECIFIC PROTEIN; CENTRAL ELEMENT; CHROMOSOME SYNAPSIS; DNA RECOMBINATION; AXIAL ELEMENTS; CAENORHABDITIS-ELEGANS; TRANSVERSE FILAMENTS; COHESIN SMC1-BETA; LATERAL ELEMENTS; SYCP3;
D O I：
10.1016/j.yexcr.2012.02.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The synaptonemal complex (SC) is a proteinaceous structure of chromosome bivalents whose assembly is indispensable for the successful progression of the first meiotic division of sexually reproducing organisms. In this mini-review we will focus on recent progress dealing with the composition and assembly of the mammalian SC. These advances mainly resulted from the systematic use of knockout mice for all known mammalian SC proteins as well as from protein polymerization studies performed in heterologous systems. (c) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：1340 / 1346
页数：7
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