Morbidity and mortality associated with Clostridium difficile ribotype 078: a case-case study

被引：20

作者：

Patterson, L. ^{[1
]}

Wilcox, M. H. ^{[2
,3
]}

Fawley, W. N. ^{[2
,3
]}

Verlander, N. Q. ^{[4
]}

Geoghegan, L. ^{[1
]}

Patel, B. C. ^{[5
]}

Wyatt, T. ^{[1
]}

Smyth, B. ^{[1
]}

机构：

[1] Publ Hlth Agcy, Hlth Protect Div, Belfast BT2 8BS, Antrim, North Ireland

[2] Leeds Gen Infirm, Old Med Sch, Leeds, W Yorkshire, England

[3] Univ Leeds, Leeds Inst Mol Med, Leeds LS2 9JT, W Yorkshire, England

[4] Hlth Protect Agcy, Stat Modelling & Econ Dept, Hlth Protect Serv, London, England

[5] Hlth Protect Agcy, London Publ Hlth Lab, London, England

来源：

JOURNAL OF HOSPITAL INFECTION | 2012年 / 82卷 / 02期

基金：

英国医学研究理事会;

关键词：

Clostridium difficile; Community; Mortality; Ribotype; 078; INFECTION;

D O I：

10.1016/j.jhin.2012.07.011

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The morbidity and mortality associated with Clostridium difficile ribotype 078 were examined by comparison with other known outbreak strains. A healthcare interaction within eight weeks of a positive specimen significantly increased the likelihood of ribotype 078 compared with ribotype 027. Individuals with ribotype 078 also tended to come from community sources, have a hospital stay post specimen similar to ribotype 027 and a lower 30-day mortality, but these differences were not statistically significant. This study generates several hypotheses and a methodological platform to explore this unique profile. (c) 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：125 / 128

页数：4

共 10 条

[1] Prospective study of Clostridium difficile infections in Europe with phenotypic and genotypic characterisation of the isolates [J].

Barbut, F. ;

Mastrantonio, P. ;

Delmee, M. ;

Brazier, J. ;

Kuijper, E. ;

Poxton, I. .

CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 (11) :1048-1057

[2] Clostridium difficile infection in Europe: a hospital-based survey [J].

Bauer, Martijn P. ;

Notermans, Daan W. ;

van Benthem, Birgit H. B. ;

Brazier, Jon S. ;

Wilcox, Mark H. ;

Rupnik, Maja ;

Monnet, Dominique L. ;

van Dissel, Jaap T. ;

Kuijper, Ed J. .

LANCET, 2011, 377 (9759) :63-73

[3] Infection due to C. difficile ribotype 078: first report of cases in the Republic of Ireland [J].

Burns, K. ;

Morris-Downes, M. ;

Fawley, W. N. ;

Smyth, E. ;

Wilcox, M. H. ;

Fitzpatrick, F. .

JOURNAL OF HOSPITAL INFECTION, 2010, 75 (04) :287-291

[4] An Enhanced DNA Fingerprinting Service To Investigate Potential Clostridium difficile Infection Case Clusters Sharing the Same PCR Ribotype [J].

Fawley, Warren N. ;

Wilcox, Mark H. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (12) :4333-4337

[5] Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078 [J].

Goorhuis, Abraham ;

Bakker, Dennis ;

Corver, Jeroen ;

Debast, Sylvia B. ;

Harmanus, Celine ;

Notermans, Daan W. ;

Bergwerff, Aldert A. ;

Dekker, Frido W. ;

Kuijper, Ed J. .

CLINICAL INFECTIOUS DISEASES, 2008, 47 (09) :1162-1170

[6]

Health Protection Agency, CLOSTR DIFF RIB NETW

[7] Clostridium difficile infection in the community: a zoonotic disease? [J].

Hensgens, M. P. M. ;

Keessen, E. C. ;

Squire, M. M. ;

Riley, T. V. ;

Koene, M. G. J. ;

de Boer, E. ;

Lipman, L. J. A. ;

Kuijper, E. J. .

CLINICAL MICROBIOLOGY AND INFECTION, 2012, 18 (07) :635-645

[8] Prevalence of PCR ribotypes among Clostridium difficile isolates from pigs, calves, and other species [J].

Keel, Kevin ;

Brazier, Jon S. ;

Post, Karen W. ;

Weese, Scott ;

Songer, J. Glenn .

JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (06) :1963-1964

[9] The economic burden of Clostridium difficile [J].

McGlone, S. M. ;

Bailey, R. R. ;

Zimmer, S. M. ;

Popovich, M. J. ;

Tian, Y. ;

Ufberg, P. ;

Muder, R. R. ;

Lee, B. Y. .

CLINICAL MICROBIOLOGY AND INFECTION, 2012, 18 (03) :282-289

[10]

Public Health Agency, 2010, C DIFF SURV OCT DEC

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