Molecular drivers of lobular carcinoma in situ

被引：29
作者：
Logan, Greg J. [1 ,2 ]
Dabbs, David J. [1 ,3 ]
Lucas, Peter C. [1 ,3 ]
Jankowitz, Rachel C. [1 ,4 ]
Brown, Daniel D. [1 ,5 ]
Clark, Beth Z. [1 ,3 ]
Oesterreich, Steffi [1 ,2 ]
McAuliffe, Priscilla F. [1 ,5 ]
机构：
[1] Univ Pittsburgh, Womens Canc Res Ctr, Inst Canc, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA
[3] Magee Womens Hosp, Dept Pathol, Pittsburgh, PA 15213 USA
[4] Univ Pittsburgh, Sch Med, Dept Med, Div Med Oncol, Pittsburgh, PA 15213 USA
[5] Univ Pittsburgh, Sch Med, Dept Surg, Div Surg Oncol, Pittsburgh, PA 15213 USA
来源：
BREAST CANCER RESEARCH | 2015年 / 17卷
关键词：
INVASIVE BREAST-CANCER; COMPARATIVE GENOMIC HYBRIDIZATION; GENE-EXPRESSION PATTERNS; ESTROGEN-RECEPTOR-ALPHA; COLUMNAR CELL LESIONS; FOLLOW-UP; INTRAEPITHELIAL NEOPLASIA; CLINICAL-IMPLICATIONS; DUCTAL CARCINOMA; TUMOR CHARACTERISTICS;
D O I：
10.1186/s13058-015-0580-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). Many LCIS lesions do not progress to ILC, and the molecular changes that are necessary for progression from LCIS to ILC are poorly understood. Disruption in the E-cadherin complex is the hallmark of lobular lesions, but other signaling molecules, such as PIK3CA and c-src, are consistently altered in LCIS. This review focuses on the molecular drivers of lobular carcinoma, a more complete understanding of which may give perspective on which LCIS lesions progress, and which will not, thus having immense clinical implications.
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页数：10
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