The potential of phage display virions expressing malignant tumor specific antigen MAGE-A1 epitope in murine model

被引：45
作者：
Fang, JB [1 ]
Wang, GY [1 ]
Yang, Q [1 ]
Song, JN [1 ]
Wang, Y [1 ]
Wang, L [1 ]
机构：
[1] NE Normal Univ, Sch Life Sci, Changchun 130024, Peoples R China
来源：
VACCINE | 2005年 / 23卷 / 40期
基金：
中国国家自然科学基金;
关键词：
tumor specific antigen; anti-tumor immunity; bacteriophage display;
D O I：
10.1016/j.vaccine.2005.05.024
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The tumor specific antigen epitope melanoma antigen A1(161-169) (MAGE-A1(161-169)) was displayed on the major protein (pVIII) of the filamentous bacteriophage (fd). The immune responses of the phage display particles expressing MAGE-A1161-169 in mice were studied. Using phage display particles as vaccine was effective in affording protection from tumor growth, inducing growth control of established tumors and prolonging survival of tumor-bearing mice. The hybrid phage particles elicited MAGE-A1(161-169) specific CTL responses, NK activity and DTH. Our results showed that the phage display particles might be a new vaccine candidate for tumor-associated antigen epitope in cancer immunotherapy. (c) 2005 Published by Elsevier Ltd.
引用
收藏
页码：4860 / 4866
页数：7
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