The potential of phage display virions expressing malignant tumor specific antigen MAGE-A1 epitope in murine model

被引：46

作者：

Fang, JB ^{[1
]}

Wang, GY ^{[1
]}

Yang, Q ^{[1
]}

Song, JN ^{[1
]}

Wang, Y ^{[1
]}

Wang, L ^{[1
]}

机构：

[1] NE Normal Univ, Sch Life Sci, Changchun 130024, Peoples R China

来源：

VACCINE | 2005年 / 23卷 / 40期

基金：

中国国家自然科学基金;

关键词：

tumor specific antigen; anti-tumor immunity; bacteriophage display;

D O I：

10.1016/j.vaccine.2005.05.024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The tumor specific antigen epitope melanoma antigen A1(161-169) (MAGE-A1(161-169)) was displayed on the major protein (pVIII) of the filamentous bacteriophage (fd). The immune responses of the phage display particles expressing MAGE-A1161-169 in mice were studied. Using phage display particles as vaccine was effective in affording protection from tumor growth, inducing growth control of established tumors and prolonging survival of tumor-bearing mice. The hybrid phage particles elicited MAGE-A1(161-169) specific CTL responses, NK activity and DTH. Our results showed that the phage display particles might be a new vaccine candidate for tumor-associated antigen epitope in cancer immunotherapy. (c) 2005 Published by Elsevier Ltd.

引用

页码：4860 / 4866

页数：7

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