Chemokine receptor internalization and intracellular trafficking

被引：180
作者：
Neel, NF
Schutyser, E
Sai, J
Fan, GH
Richmond, A
机构：
[1] Vanderbilt Univ, Sch Med, Dept Vet Affairs Med Ctr, Dept Canc Biol, Nashville, TN 37232 USA
[2] Meharry Med Coll, Dept Pharmacol, Nashville, TN 37208 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 06期
关键词：
chemokine receptor; internalization; trafficking; endocytosis; modifications;
D O I：
10.1016/j.cytogfr.2005.05.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The internalization and intracellular trafficking of chemokine receptors have important implications for the cellular responses elicited by chemokine receptors. The major pathway by which chemokine receptors internalize is the clathrin-mediated pathway, but some receptors may utilize lipid rafts/caveolae-dependent internalization routes. This review discusses the current knowledge and controversies regarding these two different routes of endocytosis. The functional consequences of internalization and the regulation of chemokine receptor recycling will also be addressed. Modifications of chemokine receptors, such as palmitoylation, ubiquitination, glycosylation, and sulfation, may also impact trafficking, chemotaxis and signaling. Finally, this review will cover the internalization and trafficking of viral and decoy chemokine receptors. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：637 / 658
页数：22
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