EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report

被引：76

作者：

Flucke, Uta ^{[1
]}

Mentzel, Thomas ^{[2
]}

Verdijk, Marian A. ^{[1
]}

Slootweg, Pieter J. ^{[1
]}

Creytens, David H. ^{[3
]}

Suurmeijer, Albert J. H. ^{[4
]}

Tops, Bastiaan B. J. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, NL-6500 HB Nijmegen, Netherlands

[2] Dermatopathol Bodensee, Friedrichshafen, Germany

[3] Univ Antwerp Hosp, Dept Pathol, Antwerp, Belgium

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands

来源：

HUMAN PATHOLOGY | 2012年 / 43卷 / 05期

关键词：

Myoepithelial tumor; Soft tissue; EWSR1-ATF1; fusion; CLEAR-CELL-SARCOMA; MOLECULAR ANALYSIS; SALIVARY-GLAND; MIXED TUMORS; PARTS; MELANOMA; FUSION;

D O I：

10.1016/j.humpath.2011.08.004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue myoepithelioma arising in the pelvis with an EWSR1-ATF1 fusion, therefore extending the spectrum of partner genes of EWSR1. In addition, this case indicates that there are overlapping genetic features of myoepithelial tumors, clear cell sarcoma, angiomatoid fibrous histiocytoma, and hyalinizing clear-cell carcinoma of the salivary gland. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：764 / 768

页数：5

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