Toxicity of PEG-Coated CoFe2O4 Nanoparticles with Treatment Effect of Curcumin

被引：16

作者：

Akhtar, Shahnaz ^{[1
]}

An, Wenzhen ^{[1
]}

Niu, Xiaoying ^{[2
]}

Li, Kang ^{[1
]}

Anwar, Shahzad ^{[3
]}

Maaz, Khan ^{[4
]}

Maqbool, Muhammad ^{[5
]}

Gao, Lan ^{[1
]}

机构：

[1] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China

[2] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China

[3] Chartered Univ, Islamia Coll Peshawar, Dept Phys, Peshawar 25120, Pakistan

[4] PINSTECH, Phys Div, Nanomat Res Grp, Islamabad 45650, Pakistan

[5] Univ Alabama Birmingham, Dept Clin & Diagnost Sci, Birmingham, AL 35294 USA

来源：

NANOSCALE RESEARCH LETTERS | 2018年 / 13卷

基金：

中国国家自然科学基金;

关键词：

Nanoparticles; Hydrothermal technique; Annealing; Toxicity; PEG-coated CoFe2O4; MAGNETIC NANOPARTICLES; TEMPERATURE;

D O I：

10.1186/s11671-018-2468-7

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this work, CoFe2O4 nanoparticles coated with polyethylene glycol (PEG) were successfully synthesized via a hydrothermal technique. Morphological studies of the samples confirmed the formation of polycrystalline pure-phase PEG-CoFe2O4 nanoparticles with sizes of about 24 nm. Toxicity induced by CoFe2O4 nanoparticles was investigated, and biological assays were performed to check the toxicity effects of CoFe2O4 nanoparticles. Moreover, the healing effect of toxicity induced in living organisms was studied using curcumin and it was found that biochemical indexes detoxified and improved to reach its normal level after curcumin administration. Thus, PEG-coated CoFe2O4 synthesized through a hydrothermal method can be utilized in biomedical applications and curcumin, which is a natural chemical with no side effects, can be used for the treatment of toxicity induced by the nanoparticles in living organisms.

引用

页数：8

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