Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

被引：338

作者：

Glaser, Stefan P. ^{[1
,2
]}

Lee, Erinna F. ^{[1
,2
]}

Trounson, Evelyn ^{[1
]}

Bouillet, Philippe ^{[1
,2
]}

Wei, Andrew ^{[3
,4
]}

Fairlie, W. Douglas ^{[1
,2
]}

Izon, David J. ^{[5
]}

Zuber, Johannes ^{[6
,7
]}

Rappaport, Amy R. ^{[6
,8
]}

Herold, Marco J. ^{[1
,2
]}

Alexander, Warren S. ^{[1
,2
]}

Lowe, Scott W. ^{[6
,8
,9
]}

Robb, Lorraine ^{[1
,2
]}

Strasser, Andreas ^{[1
,2
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia

[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3010, Australia

[3] Alfred Hosp, Australian Ctr Blood Dis, Melbourne, Vic 3004, Australia

[4] Monash Univ, Melbourne, Vic 3004, Australia

[5] St Vincents Inst, Fitzroy, Vic 3065, Australia

[6] Cold Spring Harbor Labs, Cold Spring Harbor, NY 11724 USA

[7] Res Inst Mol Pathol IMP, A-1030 Vienna, Austria

[8] Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

[9] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

来源：

GENES & DEVELOPMENT | 2012年 / 26卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

acute myeloid leukemia; apoptosis; Mcl-1; Bcl-x(L); MARROW-CELLS; STEM-CELLS; PROTEINS; GENE; CHEMOTHERAPY; EXPRESSION; SURVIVAL; BINDING; FAMILY; MICE;

D O I：

10.1101/gad.182980.111

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acute myeloid leukemia (AML) frequently relapses after initial treatment. Drug resistance in AML has been attributed to high levels of the anti-apoptotic Bcl-2 family members Bcl-x(L) and Mcl-1. Here we report that removal of Mcl-1, but not loss or pharmacological blockade of Bcl-x(L), Bcl-2, or Bcl-w, caused the death of transformed AML and could cure disease in AML-afflicted mice. Enforced expression of selective inhibitors of prosurvival Bcl-2 family members revealed that Mcl-1 is critical for survival of human AML cells. Thus, targeting of Mcl-1 or regulators of its expression may be a useful strategy for the treatment of AML.

引用

页码：120 / 125

页数：6

共 50 条

[1] Anti-apoptotic capacity of Mcl-1Δ127
Wang, Yong
Su, Wenhua
Mai, Zihao
Yu, Si
Wang, Xiaoping
Chen, Tongsheng
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 526 (04) : 1042 - 1048
[2] BAG1: The Guardian of Anti-Apoptotic Proteins in Acute Myeloid Leukemia
Aveic, Sanja
Pigazzi, Martina
Basso, Giuseppe
PLOS ONE, 2011, 6 (10):
[3] Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors
Hsu, Kai-Hsi
Tsai, Hung-Wen
Lin, Pin-Wen
Hsu, Yun-Shang
Lu, Pei-Jung
Shan, Yan-Shen
WORLD JOURNAL OF SURGICAL ONCOLOGY, 2014, 12
[4] Overexpression of KDM4D promotes acute myeloid leukemia cell development by activating MCL-1
Wu, Wei
Cao, Xiaonian
Mo, Luxia
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2021, 13 (04): : 2308 - 2319
[5] Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma
Fleischer, B
Schulze-Bergkamen, H
Schuchmann, M
Weber, A
Biesterfeld, S
Müller, M
Krammer, PH
Galle, PR
INTERNATIONAL JOURNAL OF ONCOLOGY, 2006, 28 (01) : 25 - 32
[6] Serine 162, an Essential Residue for the Mitochondrial Localization, Stability and Anti-Apoptotic Function of Mcl-1
Thomas, Luke W.
Lam, Connie
Clark, Richard E.
White, Michael R. H.
Spiller, David G.
Moots, Robert J.
Edwards, Steven W.
PLOS ONE, 2012, 7 (09):
[7] ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1
Day, Bryan W.
Stringer, Brett W.
Spanevello, Mark D.
Charmsaz, Sara
Jamieson, Paul R.
Ensbey, Kathleen S.
Carter, Jacinta C.
Cox, Joanne M.
Ellis, Vicky J.
Brown, Christopher L.
Walker, David G.
Inglis, Po L.
Allan, Suzanne
Reynolds, Brent A.
Lickliter, Jason D.
Boyd, Andrew W.
NEURO-ONCOLOGY, 2011, 13 (11) : 1202 - 1212
[8] Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours
Sano, M
Nakanishi, Y
Yagasaki, H
Honma, T
Oinuma, T
Obana, Y
Suzuki, A
Nemoto, N
HISTOPATHOLOGY, 2005, 46 (05) : 532 - 539
[9] Drug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1
Bourafai-Aziez, Asma
Benabderrahmane, Mohammed
Paysant, Hippolyte
Weiswald, Louis-Bastien
Poulain, Laurent
Carlier, Ludovic
Ravault, Delphine
Jouanne, Marie
Coadou, Gael
Oulyadi, Hassan
Voisin-Chiret, Anne-Sophie
Oliveira, Jana Sopkova-de Santos
Sebban, Muriel
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 15 : 5035 - 5059
[10] Binding affinity of pro-apoptotic BH3 peptides for the anti-apoptotic Mcl-1 and A1 proteins: Molecular dynamics simulations of Mcl-1 and A1 in complex with six different BH3 peptides
Modi, Vivek
Sankararamakrishnan, Ramasubbu
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2017, 73 : 115 - 128

← 1 2 3 4 5 →