COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome?

被引：192

作者：

Colafrancesco, Serena ^{[1
]}

Alessandri, Cristiano ^{[1
]}

Conti, Fabrizio ^{[1
]}

Priori, Roberta ^{[1
]}

机构：

[1] Sapienza Univ Rome, Rheumatol Unit, Dipartimento Sci Clin Internist Anestesiol & Card, Rome, Italy

来源：

AUTOIMMUNITY REVIEWS | 2020年 / 19卷 / 07期

关键词：

COVID-19; Cytokine storm; Inflammation; Ferritin; MACROPHAGE ACTIVATION SYNDROME; ONSET STILLS-DISEASE; INTERFERON-GAMMA; FERRITIN; CYTOKINE; PROTEIN;

D O I：

10.1016/j.autrev.2020.102573

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term "hyperferritinemic syndromes" and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic inflammatory reaction and "hyperferritinemic syndromes" are all characterized by high serum ferritin and a life-threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi-organ failure. In this review, we analyze the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and we underline the similarities between this condition and "hyperferritinemic syndromes"which would allow considering severe COVID-19 as a fifth member of this spectrum of inflammatory conditions.

引用

页数：5

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