Complete pathological response of post neoadjuvant chemotherapy in colorectal cancer with liver metastasis: a case report

被引：2
作者：
Al Jazzar, Ragad, I [1 ]
Algarni, Mohammed [2 ]
Al-Maiman, Sarah [3 ]
Alzahrani, Nayef [4 ]
机构：
[1] King Saud bin Abdulaziz Univ Hlth Sci, Coll Med, POB 7489, Riyadh, Saudi Arabia
[2] King Saud bin Abdulaziz Univ Hlth Sci, Minist Natl Guard Hlth Affairs, King Abdullah Int Med Res Ctr, Onol Dept, Riyadh, Saudi Arabia
[3] Minist Natl Guard Hlth Affairs, King Abdulaziz Med City, Anat Pathol GI Pancreatobillary & Liver Pathol, Riyadh, Saudi Arabia
[4] Minist Natl Guard Hlth Affairs, King Abdulaziz Med City, Dept Surg, Riyadh, Saudi Arabia
来源：
JOURNAL OF SURGICAL CASE REPORTS | 2022年 / 2022卷 / 02期
关键词：
SURVIVAL; RESECTION;
D O I：
10.1093/jscr/rjac041
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Treatment of metastatic colorectal cancer has evolved throughout the years and various methods have been proposed to reach a pathological complete response state. We report a case of a 73-year-old male presented with a sigmoid adenocarcinoma with two synchronous liver metastases. The patient received five cycles of FOLFOX neoadjuvant chemotherapy, 41% reduction of tumor size was noted upon reassessment. Therefore, a low anterior resection of the rectum and synchronous resection of segment 5 and 8 of the liver was done along with right-sided diaphragmatic stripping. A pathological complete response was achieved in both primary and secondary tumors that are considered rare and challenging in metastatic colorectal cancer. Neoadjuvant chemotherapy showed promising findings in advanced colorectal cancer.
引用
收藏
页数：3
相关论文
共 12 条
[1]   Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: Myth or reality? [J].
Adam, Rene ;
Wicherts, Dennis A. ;
de Haas, Robbert J. ;
Aloia, Thomas ;
Levi, Francis ;
Paule, Bernard ;
Guettier, Catherine ;
Kunstlinger, Francis ;
Delvart, Valerie ;
Azoulay, Daniel ;
Castaing, Denis .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (10) :1635-1641
[2]  
Al-Zahrani M., 2016, SCR ANN REPORTS
[3]  
[Anonymous], 2021, CANC
[4]   Chemotherapy for Patients with Colorectal Liver Metastases Who Underwent Curative Resection Improves Long-Term Outcomes: Systematic Review and Meta-analysis [J].
Araujo, Raphael L. C. ;
Goenen, Mithat ;
Herman, Paulo .
ANNALS OF SURGICAL ONCOLOGY, 2015, 22 (09) :3070-3078
[5]   IMPACT OF GENETICS ON NEOADJUVANT THERAPY WITH COMPLETE PATHOLOGICAL RESPONSE IN METASTATIC COLORECTAL CANCER: CASE REPORT AND REVIEW OF THE LITERATURE [J].
Bulajic, P. ;
Bidzic, N. ;
Djordjevic, V ;
Ceranic, M. ;
Basaric, D. ;
Pesic, V ;
Djordjevic-Pesic, J. .
BALKAN JOURNAL OF MEDICAL GENETICS, 2019, 22 (01) :75-80
[6]   'Liver-first' approach for metastatic colorectal cancer [J].
Donati, Marcello ;
Stavrou, Gregor A. ;
Stang, Axel ;
Basile, Francesco ;
Oldhafer, Karl J. .
FUTURE ONCOLOGY, 2015, 11 (08) :1233-1243
[7]   Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial [J].
Nordlinger, Bernard ;
Sorbye, Halfdan ;
Glimelius, Bengt ;
Poston, Graeme J. ;
Schlag, Peter M. ;
Rougier, Philippe ;
Bechstein, Wolf O. ;
Primrose, John N. ;
Walpole, Euan T. ;
Finch-Jones, Meg ;
Jaeck, Daniel ;
Mirza, Darius ;
Parks, Rowan W. ;
Mauer, Murielle ;
Tanis, Erik ;
Van Cutsem, Eric ;
Scheithauer, Werner ;
Gruenberger, Thomas .
LANCET ONCOLOGY, 2013, 14 (12) :1208-1215
[8]  
Recio-Boiles A., 2021, COLON CANC
[9]   Actual 10-year survival after resection of colorectal liver Metastases defines cure [J].
Tomlinson, James S. ;
Jarnagin, William R. ;
DeMatteo, Ronald P. ;
Fong, Yuman ;
Kornprat, Peter ;
Gonen, Mithat ;
Kemeny, Nancy ;
Brennan, Murray F. ;
Blumgart, Leslie H. ;
D'Angelica, Michael .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (29) :4575-4580
[10]   Nationwide trends in incidence, treatment and survival of colorectal cancer patients with synchronous metastases [J].
van der Geest, Lydia G. M. ;
Lam-Boer, Jorine't ;
Koopman, Miriam ;
Verhoef, Cees ;
Elferink, Marloes A. G. ;
de Wilt, Johannes H. W. .
CLINICAL & EXPERIMENTAL METASTASIS, 2015, 32 (05) :457-465
12