Stress-induced sickness behaviors: An alternative hypothesis for responses during maternal separation

被引:46
|
作者
Hennessy, MB [1 ]
Deak, T
Schiml-Webb, PA
机构
[1] Wright State Univ, Dept Psychol, Dayton, OH 45435 USA
[2] Naval Hlth Res Ctr, Wright Patterson AFB, OH 45433 USA
关键词
maternal separation; isolation; acute phase response; sickness behaviors; despair; depression; immune response; cytokines; corticotropin-releasing factor; guinea pig;
D O I
10.1002/dev.1031
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
During maternal separation, some primate and nonprimate species show a biphasic (active/passive) response. The second stage is characterized by reduced activity a hunched body posture, and other behaviors. Traditionally, the second stage has been referred to as "despair" and is considered an animal model for human depression. Recent research in psychoneuroimmunology suggests an alternative hypothesis-that behaviors occurring during the second passive phase represent stress-induced "sickness behaviors." This perspective more readily accounts for findings in widely divergent species', does not require assumptions regarding the ability to express complex emotional states, is empirically testable, and aligns the separation model with recent hypotheses regarding the nature and ontogeny of depressive illness. (C) 2001 John Wiley & Sons, Inc.
引用
收藏
页码:76 / 83
页数:8
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