Autologous Haematopoietic Stem Cell Transplantation and Systemic Sclerosis: Focus on Interstitial Lung Disease

被引：6

作者：

Bagnato, Gianluca ^{[1
]}

Versace, Antonio Giovanni ^{[1
]}

La Rosa, Daniela ^{[1
]}

De Gaetano, Alberta ^{[1
]}

Imbalzano, Egidio ^{[1
]}

Chiappalone, Marianna ^{[1
]}

Ioppolo, Carmelo ^{[1
]}

Roberts, William Neal ^{[2
]}

Bitto, Alessandra ^{[1
]}

Irrera, Natasha ^{[1
]}

Allegra, Alessandro ^{[1
]}

Pioggia, Giovanni ^{[3
]}

Gangemi, Sebastiano ^{[1
]}

机构：

[1] Univ Messina, Dept Clin & Expt Med, I-98125 Messina, Italy

[2] Univ Kentucky, Dept Med, Lexington, KY 40506 USA

[3] Natl Res Council Italy, Inst Biomed Res & Innovat, I-98125 Messina, Italy

来源：

CELLS | 2022年 / 11卷 / 05期

关键词：

systemic sclerosis; interstitial lung disease; hematopoietic stem cells transplantation; DOSE IMMUNOSUPPRESSIVE THERAPY; TERM-FOLLOW-UP; AUTOIMMUNE-DISEASES; PULSE CYCLOPHOSPHAMIDE; DOUBLE-BLIND; RECOMMENDATIONS; MYCOPHENOLATE; MORTALITY; EVOLUTION; OUTCOMES;

D O I：

10.3390/cells11050843

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autologous hematopoietic stem cells transplantation (AHSCT) has been employed as treatment for severe systemic sclerosis (SSc) with high risk of organ failure. In the last 25 years overall survival and treatment-related mortality have improved, in accordance with a better patient selection and mobilization and conditioning protocols. This review analyzes the evidence from the last 5 years for AHSCT-treated SSc patients, considering in particular the outcomes related to interstitial lung disease. There are increasing data supporting the use of AHSCT in selected patients with rapidly progressive SSc. However, some unmet needs remain, such as an accurate patient selection, pre-transplantation analysis to identify subclinical conditions precluding the transplantation, and the alternatives for post-transplant ILD recurrence.

引用

页数：12

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