Prenatal ultrasonographic prediction of homozygous type 1 α-thalassemia at 12 to 13 weeks of gestation

被引：75

作者：

Lam, YH ^{[1
]}

Tang, MHY ^{[1
]}

Lee, CP ^{[1
]}

Tse, HY ^{[1
]}

机构：

[1] Kwong Wah Hosp, Dept Obstet & Gynecol, Hong Kong, Peoples R China

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1999年 / 180卷 / 01期

关键词：

ultrasonography; fetal heart; alpha-thalassemia; prenatal diagnosis;

D O I：

10.1016/S0002-9378(99)70165-1

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We determined the feasibility of prenatal prediction of type 1 homozygous alpha-thalassemia at 12 to 13 weeks of gestation by either abdominal or Vaginal (or both) ultrasonographic examination to measure the fetal cardiothoracic ratio in 135 at-risk pregnancies. Forty-three fetuses were affected by homozygous type 1 alpha-thalassemia. The mean cardiothoracic ratio was significantly larger than that of the unaffected fetuses (0.54 vs 0.45, P < .0005), with no overlap between the 2 groups. A cardiothoracic ratio cutoff point of greater than or equal to 0.5 was 100% sensitive and specific for disease.

引用

页码：148 / 150

页数：3