Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and Treatment

被引：11

作者：

Gonzalez, Luis O. ^{[1
]}

Eiro, Noemi ^{[2
]}

Fraile, Maria ^{[2
]}

Beridze, Nana ^{[2
]}

Escaf, Andres R. ^{[2
]}

Escaf, Safwan ^{[3
]}

Fernandez-Gomez, Jesus M. ^{[3
]}

Vizoso, Francisco J. ^{[2
,4
]}

机构：

[1] Fdn Hosp Jove, Dept Anat Pathol, Avda Eduardo Castro 161, Gijon 33920, Spain

[2] Fdn Hosp Jove, Res Unit, Avda Eduardo Castro 161, Gijon 33920, Spain

[3] Univ Oviedo, Hosp Univ Cent Asturias, Dept Urol, Avda Roma S-N, Oviedo 33011, Spain

[4] Fdn Hosp Jove, Dept Surg, Avda Eduardo Castro 161, Gijon 33920, Spain

来源：

CANCERS | 2022年 / 14卷 / 18期

关键词：

cancer-associated fibroblasts; mesenchymal stromal cells; tumor microenvironment; extracellular vesicles; exosomes; biochemical recurrence in prostate cancer; MESENCHYMAL STEM-CELLS; ANDROGEN DEPRIVATION THERAPY; BREAST-CANCER; EXTRACELLULAR-MATRIX; REACTIVE STROMA; GENE-EXPRESSION; PHASE-II; MICROENVIRONMENTAL REGULATION; CLINICAL-SIGNIFICANCE; MYOEPITHELIAL CELLS;

D O I：

10.3390/cancers14184412

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer (PCa) is a common cancer among males globally, and its occurrence is growing worldwide. Clinical decisions about the combination of therapies are becoming highly relevant. However, this is a heterogeneous disease, ranging widely in prognosis. Therefore, new approaches are needed based on tumor biology, from which further prognostic assessments can be established and complementary strategies can be identified. The knowledge of both the morphological structure and functional biology of the PCa stroma compartment can provide new diagnostic, prognostic or therapeutic possibilities. In the present review, we analyzed the aspects related to the tumor stromal component (both acellular and cellular) in PCa, their influence on tumor behavior and the therapeutic response and their consideration as a new therapeutic target.

引用

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