Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis

被引：38

作者：

Berntsen, Natalie L. ^{[1
,2
,5
,6
]}

Klingenberg, Olav ^{[3
,5
]}

Juran, Brian D. ^{[7
]}

de Valle, Maria Benito ^{[8
]}

Lindkvist, Bjorn ^{[8
]}

Lazaridis, Konstantinos N. ^{[8
]}

Boberg, Kirsten Muri ^{[1
,4
,5
]}

Karlsen, Tom H. ^{[1
,2
,4
,5
,6
]}

Hov, Johannes Roksund ^{[1
,2
,4
,5
,6
]}

机构：

[1] Natl Hosp Norway, Oslo Univ Hosp, Norwegian Primary Sclerosing Cholangitis Res Ctr, N-0424 Oslo, Norway

[2] Natl Hosp Norway, Oslo Univ Hosp, Res Inst Internal Med, Div Canc Med Surg & Transplantat, N-0424 Oslo, Norway

[3] Natl Hosp Norway, Oslo Univ Hosp, Dept Med Biochem, N-0424 Oslo, Norway

[4] Natl Hosp Norway, Oslo Univ Hosp, Div Canc Med Surg & Transplantat, Sect Gastroenterol,Dept Transplantat Med, N-0424 Oslo, Norway

[5] Univ Oslo, Inst Clin Med, N-0316 Oslo, Norway

[6] Univ Oslo, Fac Med, Inst Clin Med, KG Jebsen Inflammat Res Ctr, N-0316 Oslo, Norway

[7] Mayo Clin, Coll Med, Ctr Basic Res Digest Dis, Div Gastroenterol & Hepatol, Rochester, MN USA

[8] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden

来源：

GASTROENTEROLOGY | 2015年 / 148卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Genetic Association Study; Immunogenetics; IgG4-Associated Cholangitis; Immune Response; IMMUNOGLOBULIN G4-ASSOCIATED CHOLANGITIS; GENETIC ASSOCIATIONS; ALLELES; DISEASE; MODEL; DR3; G4;

D O I：

10.1053/j.gastro.2015.01.041

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B*08, than patients without increased IgG4, and significantly higher frequencies of HLA-B*07 and HLA-DRB1*15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.

引用

页码：924 / U355

页数：6

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