Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis

被引：37
作者：
Berntsen, Natalie L. [1 ,2 ,5 ,6 ]
Klingenberg, Olav [3 ,5 ]
Juran, Brian D. [7 ]
de Valle, Maria Benito [8 ]
Lindkvist, Bjorn [8 ]
Lazaridis, Konstantinos N. [8 ]
Boberg, Kirsten Muri [1 ,4 ,5 ]
Karlsen, Tom H. [1 ,2 ,4 ,5 ,6 ]
Hov, Johannes Roksund [1 ,2 ,4 ,5 ,6 ]
机构：
[1] Natl Hosp Norway, Oslo Univ Hosp, Norwegian Primary Sclerosing Cholangitis Res Ctr, N-0424 Oslo, Norway
[2] Natl Hosp Norway, Oslo Univ Hosp, Res Inst Internal Med, Div Canc Med Surg & Transplantat, N-0424 Oslo, Norway
[3] Natl Hosp Norway, Oslo Univ Hosp, Dept Med Biochem, N-0424 Oslo, Norway
[4] Natl Hosp Norway, Oslo Univ Hosp, Div Canc Med Surg & Transplantat, Sect Gastroenterol,Dept Transplantat Med, N-0424 Oslo, Norway
[5] Univ Oslo, Inst Clin Med, N-0316 Oslo, Norway
[6] Univ Oslo, Fac Med, Inst Clin Med, KG Jebsen Inflammat Res Ctr, N-0316 Oslo, Norway
[7] Mayo Clin, Coll Med, Ctr Basic Res Digest Dis, Div Gastroenterol & Hepatol, Rochester, MN USA
[8] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden
来源：
GASTROENTEROLOGY | 2015年 / 148卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Genetic Association Study; Immunogenetics; IgG4-Associated Cholangitis; Immune Response; IMMUNOGLOBULIN G4-ASSOCIATED CHOLANGITIS; GENETIC ASSOCIATIONS; ALLELES; DISEASE; MODEL; DR3; G4;
D O I：
10.1053/j.gastro.2015.01.041
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B*08, than patients without increased IgG4, and significantly higher frequencies of HLA-B*07 and HLA-DRB1*15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.
引用
收藏
页码：924 / U355
页数：6
相关论文
共 24 条
  • [1] Time-dependent Cox regression model is superior in prediction of prognosis in primary sclerosing cholangitis
    Boberg, KM
    Rocca, G
    Egeland, T
    Bergquist, A
    Broomé, U
    Caballeria, L
    Chapman, R
    Hultcrantz, R
    Mitchell, S
    Pares, A
    Rosina, F
    Schrumpf, E
    [J]. HEPATOLOGY, 2002, 35 (03) : 652 - 657
  • [2] Serum Immunoglobulin G4 and Immunoglobulin G1 for Distinguishing Immunoglobulin G4-Associated Cholangitis From Primary Sclerosing Cholangitis
    Boonstra, Kirsten
    Culver, Emma L.
    Wenniger, Lucas Maillette de Buy
    van Heerde, Marianne J.
    van Erpecum, Karel J.
    Poen, Alexander C.
    van Nieuwkerk, Karin M. J.
    Spanier, B. W. Marcel
    Witteman, Ben J. M.
    Tuynman, Hans A. R. E.
    van Geloven, Nan
    van Buuren, Henk
    Chapman, Roger W.
    Barnes, Eleanor
    Beuers, Ulrich
    Ponsioen, Cyriel Y.
    [J]. HEPATOLOGY, 2014, 59 (05) : 1954 - 1963
  • [3] PRIMARY SCLEROSING CHOLANGITIS - A REVIEW OF ITS CLINICAL-FEATURES, CHOLANGIOGRAPHY, AND HEPATIC HISTOLOGY
    CHAPMAN, RWG
    ARBORGH, BAM
    RHODES, JM
    SUMMERFIELD, JA
    DICK, R
    SCHEUER, PJ
    SHERLOCK, S
    [J]. GUT, 1980, 21 (10) : 870 - 877
  • [4] Problems of reporting genetic associations with complex outcomes
    Colhoun, HM
    McKeigue, PM
    Smith, GD
    [J]. LANCET, 2003, 361 (9360) : 865 - 872
  • [5] The impact of elevated serum IgG4 levels in patients with primary sclerosing cholangitis
    de Valle, Maria Benito
    Mueller, Tobias
    Bjoernsson, Einar
    Otten, Morgane
    Volkmann, Martin
    Guckelberger, Olaf
    Wiedenmann, Bertram
    Sadik, Riadh
    Schott, Eckart
    Andersson, Mats
    Berg, Thomas
    Lindkvist, Bjoern
    [J]. DIGESTIVE AND LIVER DISEASE, 2014, 46 (10) : 903 - 908
  • [6] HLA*IMP-an integrated framework for imputing classical HLA alleles from SNP genotypes
    Dilthey, Alexander T.
    Moutsianas, Loukas
    Leslie, Stephen
    McVean, Gil
    [J]. BIOINFORMATICS, 2011, 27 (07) : 968 - 972
  • [7] DUAL ASSOCIATION OF HLA DR2 AND DR3 WITH PRIMARY SCLEROSING CHOLANGITIS
    DONALDSON, PT
    FARRANT, JM
    WILKINSON, ML
    HAYLLAR, K
    PORTMANN, BC
    WILLIAMS, R
    [J]. HEPATOLOGY, 1991, 13 (01) : 129 - 133
  • [8] Immunoglobulin G4-associated cholangitis: Clinical profile and response to therapy
    Ghazale, Amaar
    Chari, Suresh T.
    Zhang, Lizhi
    Smyrk, Thomas C.
    Takahashi, Naoki
    Levy, Michael J.
    Topazian, Mark D.
    Clain, Jonathan E.
    Pearson, Randall K.
    Petersen, Bret T.
    Vege, Santhi Swaroop
    Lindor, Keith
    Farnell, Michael B.
    [J]. GASTROENTEROLOGY, 2008, 134 (03) : 706 - 715
  • [9] Primary sclerosing cholangitis
    Hirschfield, Gideon M.
    Karlsen, Tom H.
    Lindor, Keith D.
    Adams, David H.
    [J]. LANCET, 2013, 382 (9904) : 1587 - 1599
  • [10] Electrostatic Modifications of the Human Leukocyte Antigen-DR P9 Peptide-Binding Pocket and Susceptibility to Primary Sclerosing Cholangitis
    Hov, Johannes R.
    Kosmoliaptsis, Vasilis
    Traherne, James A.
    Olsson, Marita
    Boberg, Kirsten M.
    Bergquist, Annika
    Schrumpf, Erik
    Bradley, J. Andrew
    Taylor, Craig J.
    Lie, Benedicte A.
    Trowsdale, John
    Karlsen, Tom H.
    [J]. HEPATOLOGY, 2011, 53 (06) : 1967 - 1976
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