New flavonol glycoside from Scabiosa prolifera L. aerial parts with in vitro antioxidant and cytotoxic activities

被引：16

作者：

Al-Qudah, Mahmoud A. ^{[1
]}

Otoom, Noor K. ^{[1
]}

Al-Jaber, Hala I. ^{[2
]}

Saleh, Ayman M. ^{[3
,4
]}

Abu Zarga, Musa H. ^{[5
]}

Afifi, Fatma U. ^{[6
]}

Abu Orabi, Sultan T. ^{[5
]}

机构：

[1] Yarmouk Univ, Dept Chem, Fac Sci, Irbid, Jordan

[2] Al Balqa Appl Univ, Dept Phys & Basic Sci, Fac Engn Technol, Amman, Jordan

[3] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Appl Med Sci, Dept Clin Lab Sci, Jeddah, Saudi Arabia

[4] KAIMRC, Jeddah, Saudi Arabia

[5] Univ Jordan, Dept Chem, Sch Sci, Amman, Jordan

[6] Univ Jordan, Dept Pharmaceut Sci, Sch Pharm, Amman, Jordan

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 24期

关键词：

Scabiosa prolifera; Dipsacaceae; kaempferol-3-O-(4; 6-di-E-p-coumaroyl)--D-galactopyranoside; antioxidant activity; cytotoxic activity; PHENOLIC-COMPOUNDS; OLEANOLIC ACID; GROWING WILD; CONSTITUENTS; DIPSACACEAE; SAPONINS; LEAVES; PLANTS;

D O I：

10.1080/14786419.2017.1305377

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation of the chemical constituents of the aerial parts of Scabiosa prolifera L. led to the isolation of one new flavonol glycoside, kaempferol-3-O-(4,6-di-E-p-coumaroyl)-- D-galactopyranoside (1), along with ten other known compounds including luteolin-7-O-(2-O-ethyl--glucopyranoside), -sitosterol, -sitosterylglucoside, ursolic acid, corosolic acid, ursolic acid 3-O--D-arabinopyranoside, apigenin, methyl--D-glucopyranoside, luteolin-7-O--glucopyranoside and isoorientin. The structures of all isolated compounds were established using chemical methods and spectroscopic methods including IR, UV, NMR (1D and 2D) and HRESIMS. All compounds were isolated for the first time from the plant. The antioxidant and cytotoxic activities of compounds 1 and 2 were also investigated. [GRAPHICS]

引用

页码：2865 / 2874

页数：10

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