Expression of Focal Adhesion Genes in Mesenchymal Stem Cells under Simulated Microgravity

被引：16

作者：

Ratushnyy, A. Yu. ^{[1
]}

Buravkova, L. B. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Biomed Problems, Khoroshevskoe Sh 76a, Moscow 123007, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2017年 / 477卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

FAK;

D O I：

10.1134/S1607672917060035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of 84 focal adhesion genes of multipotent mesenchymal stromal cells (MMSCs) after 96-h microgravity simulation at 3D clinorotation was studied. The upregulation of ITGA6, ITGA7, BCAR1, GRB2, CAV1, and DIAPH1 and the downregulation of ITGA11, ITGAV, ITGB1, PTEN, PTK2 (FAK), ARHGAP5, DOCK1, ROCK2, and AKT3 was found. These changes at the transcriptional level may be a cause of the reduction of the osteogenic potential of MMSCs and their ability to migration and adhesion in microgravity.

引用

页码：354 / 356

页数：3

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