Emergence of Epidemic Neisseria meningitidis Serogroup X Meningitis in Togo and Burkina Faso

被引：103

作者：

Delrieu, Isabelle ^{[1
]}

Yaro, Seydou ^{[2
]}

Tamekloe, Tsidi A. S. ^{[3
]}

Njanpop-Lafourcade, Berthe-Marie ^{[1
]}

Tall, Haoua ^{[1
]}

Jaillard, Philippe ^{[1
]}

Ouedraogo, Macaire S. ^{[4
]}

Badziklou, Kossi ^{[5
]}

Sanou, Oumarou ^{[1
]}

Drabo, Aly ^{[2
]}

Gessner, Bradford D. ^{[1
]}

Kambou, Jean L. ^{[6
]}

Mueller, Judith E. ^{[1
]}

机构：

[1] Agence Med Prevent, Paris, France

[2] Ctr Muraz, Bobo Dioulasso, Burkina Faso

[3] Minist Hlth, Lome, Togo

[4] Ctr Hosp Univ Souro Sanou, Bobo Dioulasso, Burkina Faso

[5] Natl Inst Hyg, Lome, Togo

[6] Minist Hlth, Ouagadougou, Burkina Faso

来源：

PLOS ONE | 2011年 / 6卷 / 05期

关键词：

MENINGOCOCCAL MENINGITIS; CARRIAGE; IMPACT; NIGER; BELT; W135;

D O I：

10.1371/journal.pone.0019513

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Serogroup X meningococci (NmX) historically have caused sporadic and clustered meningitis cases in sub-Saharan Africa. To study recent NmX epidemiology, we analyzed data from population-based, sentinel and passive surveillance, and outbreak investigations of bacterial meningitis in Togo and Burkina Faso during 2006-2010. Cerebrospinal fluid specimens were analyzed by PCR. In Togo during 2006-2009, NmX accounted for 16% of the 702 confirmed bacterial meningitis cases. Kozah district experienced an NmX outbreak in March 2007 with an NmX seasonal cumulative incidence of 33/100,000. In Burkina Faso during 2007-2010, NmX accounted for 7% of the 778 confirmed bacterial meningitis cases, with an increase from 2009 to 2010 (4% to 35% of all confirmed cases, respectively). In 2010, NmX epidemics occurred in northern and central regions of Burkina Faso; the highest district cumulative incidence of NmX was estimated as 130/100,000 during March-April. Although limited to a few districts, we have documented NmX meningitis epidemics occurring with a seasonal incidence previously only reported in the meningitis belt for NmW135 and NmA, which argues for development of an NmX vaccine.

引用

页数：8

共 24 条

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