DEVELOPMENT OF A MINIATURIZED HIFU DEVICE FOR GLAUCOMA TREATMENT WITH CONFORMAL COAGULATION OF THE CILIARY BODIES

被引：61

作者：

Charrel, Thomas ^{[1
,4
]}

Aptel, Florent ^{[1
,2
]}

Birer, Alain ^{[1
]}

Chavrier, Francoise ^{[1
]}

Romano, Fabrice ^{[4
]}

Chapelon, Jean-Yves ^{[1
]}

Denis, Philippe ^{[3
]}

Lafon, Cyril ^{[1
]}

机构：

[1] Univ Lyon, INSERM, U556, F-69424 Lyon 03, France

[2] Hop Edouard Herriot, Hosp Civils Lyon, Dept Ophthalmol, Lyon, France

[3] Croix Rousse Hosp, Dept Ophthalmol, Hosp Civils Lyon, Lyon, France

[4] EyeTechCare, Rillieux La Pape, France

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2011年 / 37卷 / 05期

关键词：

High-intensity focused ultrasound; Ocular pathology; Glaucoma; Ciliary bodies; Conformal cyclocoagulation; Medical device; High frequency; Third harmonic; THERAPEUTIC ULTRASOUND; INDUCED LESIONS; TRABECULECTOMY; ABLATION; OUTCOMES; GEL;

D O I：

10.1016/j.ultrasmedbio.2011.01.017

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

This study examined the feasibility of high-intensity focused ultrasound (HIFU) for glaucoma treatment with conformal coagulation of the ciliary bodies (CB). A miniaturized high frequency (21 MHz) device was developed, based on the geometry of the eye and adapted to the anatomy of the rabbit eyeball. Six line-focus lesions were distributed along a circle and produced by six cylindrical transducers. To be conformal, the numerical model predicted an intensity of 6.9 W/cm(2), with exposure duration of 3 s ON (powered per sector). In vivo experiments were conducted on two rabbits. A significant intraocular pressure reduction was noted (-45% and -31%). Histology demonstrated conformal and homogeneous coagulation of the CB without side effects. (E-mail: thomas.charrel@inserm.fr) (C) 2011 World Federation for Ultrasound in Medicine & Biology.

引用

页码：742 / 754

页数：13

共 54 条

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