Self-renewal related signaling in myeloid leukemia stem cells

被引：33
|
作者：
Heidel, Florian H. [1 ,2 ,3 ]
Mar, Brenton G. [1 ,2 ]
Armstrong, Scott A. [1 ,2 ,4 ]
机构：
[1] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
[3] Otto VonGuericke Univ Magdegurg, Dept Hematol Oncol, D-39016 Magdeburg, Germany
[4] Harvard Univ, Stem Cell Inst, Boston, MA 02115 USA
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2011年 / 94卷 / 02期
关键词：
Leukemia stem cell; Self-renewal; Hedgehog; Wnt; Notch; FoxO; CHRONIC MYELOGENOUS LEUKEMIA; COMPLETE MOLECULAR REMISSION; INHIBITS TUMOR-GROWTH; BETA-CATENIN; IN-VIVO; BCR-ABL; SONIC HEDGEHOG; CANCER; NOTCH; PATHWAY;
D O I：
10.1007/s12185-011-0901-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A key characteristic of hematopoietic stem cells (HSC) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSC and potentially also in leukemic stem cells. Besides pathways such as Wnt signaling, Hedgehog signaling and Notch signaling, transcription factors (FoxOs) and cell fate determinants may also play a role in stem cells. While some of these pathways seem to be dispensable for maintenance of adult HSC, there may be a distinct requirement in leukemia stem cells for leukemic self-renewal. Here we will focus on self-renewal related signaling in myeloid leukemia stem cells and its therapeutic relevance.
引用
收藏
页码：109 / 117
页数：9
相关论文
共 50 条
  • [21] Self-renewal and solid tumor stem cells
    Al-Hajj, M
    Clarke, MF
    ONCOGENE, 2004, 23 (43) : 7274 - 7282
  • [22] Mechanisms of self-renewal in hematopoietic stem cells
    Wang, Zhao
    Ema, Hideo
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2016, 103 (05) : 498 - 509
  • [23] Gastrointestinal stem cells in self-renewal and cancer
    Lin, S. Adelia
    Barker, Nick
    JOURNAL OF GASTROENTEROLOGY, 2011, 46 (09) : 1039 - 1055
  • [24] Theragnostic strategies harnessing the self-renewal pathways of stem-like cells in the acute myeloid leukemia
    Bhattacharjee, Rahul
    Ghosh, Sharad
    Nath, Arijit
    Basu, Asmita
    Biswas, Ojaswi
    Patil, Chandragauda R.
    Kundu, Chanakya Nath
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2022, 177
  • [25] Targeting self-renewal pathways in myeloid malignancies
    Sands, William A.
    Copland, Mhairi
    Wheadon, Helen
    CELL COMMUNICATION AND SIGNALING, 2013, 11
  • [26] Autophagy and Stem Cells: Self-Eating for Self-Renewal
    Chang, Natasha C.
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [27] Icariin Promotes Self-Renewal of Neural Stem Cells: An Involvement of Extracellular Regulated Kinase Signaling Pathway
    Huang Jian-hua
    Cai Wai-jiao
    Zhang Xin-min
    Shen Zi-yin
    CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2014, 20 (02) : 107 - 115
  • [28] A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression
    Kikushige, Yoshikane
    Miyamoto, Toshihiro
    Yuda, Junichiro
    Jabbarzadeh-Tabrizi, Siamak
    Shima, Takahiro
    Takayanagi, Shin-ichiro
    Niiro, Hiroaki
    Yurino, Ayano
    Miyawaki, Kohta
    Takenaka, Katsuto
    Iwasaki, Hiromi
    Akashi, Koichi
    CELL STEM CELL, 2015, 17 (03) : 341 - 352
  • [29] Mechanisms of self-renewal in human embryonic stem cells
    Stewart, Rebecca
    Stojkovic, Miodrag
    Lako, Majlinda
    EUROPEAN JOURNAL OF CANCER, 2006, 42 (09) : 1257 - 1272
  • [30] Regulation of self-renewal in normal and cancer stem cells
    Falzacappa, Maria V. Verga
    Ronchini, Chiara
    Reavie, Linsey B.
    Pelicci, Pier G.
    FEBS JOURNAL, 2012, 279 (19) : 3559 - 3572
12345