Self-renewal related signaling in myeloid leukemia stem cells

被引：33
|
作者：
Heidel, Florian H. [1 ,2 ,3 ]
Mar, Brenton G. [1 ,2 ]
Armstrong, Scott A. [1 ,2 ,4 ]
机构：
[1] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
[3] Otto VonGuericke Univ Magdegurg, Dept Hematol Oncol, D-39016 Magdeburg, Germany
[4] Harvard Univ, Stem Cell Inst, Boston, MA 02115 USA
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2011年 / 94卷 / 02期
关键词：
Leukemia stem cell; Self-renewal; Hedgehog; Wnt; Notch; FoxO; CHRONIC MYELOGENOUS LEUKEMIA; COMPLETE MOLECULAR REMISSION; INHIBITS TUMOR-GROWTH; BETA-CATENIN; IN-VIVO; BCR-ABL; SONIC HEDGEHOG; CANCER; NOTCH; PATHWAY;
D O I：
10.1007/s12185-011-0901-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A key characteristic of hematopoietic stem cells (HSC) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSC and potentially also in leukemic stem cells. Besides pathways such as Wnt signaling, Hedgehog signaling and Notch signaling, transcription factors (FoxOs) and cell fate determinants may also play a role in stem cells. While some of these pathways seem to be dispensable for maintenance of adult HSC, there may be a distinct requirement in leukemia stem cells for leukemic self-renewal. Here we will focus on self-renewal related signaling in myeloid leukemia stem cells and its therapeutic relevance.
引用
收藏
页码：109 / 117
页数：9
相关论文
共 50 条
  • [1] Self-renewal related signaling in myeloid leukemia stem cells
    Florian H. Heidel
    Brenton G. Mar
    Scott A. Armstrong
    International Journal of Hematology, 2011, 94 : 109 - 117
  • [2] Approaches for targeting self-renewal pathways in cancer stem cells: implications for hematological treatments
    Horne, Gillian A.
    Copland, Mhairi
    EXPERT OPINION ON DRUG DISCOVERY, 2017, 12 (05) : 465 - 474
  • [3] Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells
    Rajakulendran, Nishani
    Rowland, Katherine J.
    Selvadurai, Hayden J.
    Ahmadi, Moloud
    Park, Nicole I.
    Naumenko, Sergey
    Dolma, Sonam
    Ward, Ryan J.
    So, Milly
    Lee, Lilian
    MacLeod, Graham
    Pasiliao, Clarissa
    Brandon, Caroline
    Clarke, Ian D.
    Cusimano, Michael D.
    Bernstein, Mark
    Batada, Nizar
    Angers, Stephane
    Dirks, Peter B.
    GENES & DEVELOPMENT, 2019, 33 (9-10) : 498 - 510
  • [4] Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
    van der Flier, Laurens G.
    Clevers, Hans
    ANNUAL REVIEW OF PHYSIOLOGY, 2009, 71 : 241 - 260
  • [5] Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?
    Belmonte, M.
    Hoofd, C.
    Weng, A. P.
    Giambra, V.
    CURRENT ONCOLOGY, 2016, 23 (01) : 34 - 41
  • [6] Self-Renewal and Pluripotency in Osteosarcoma Stem Cells' Chemoresistance: Notch, Hedgehog, and Wnt/β-Catenin Interplay with Embryonic Markers
    Martins-Neves, Sara R. R.
    Sampaio-Ribeiro, Gabriela
    Gomes, Celia M. F.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (09)
  • [7] Wingless promotes EGFR signaling in follicle stem cells to maintain self-renewal
    Kim-Yip, Rebecca P.
    Nystul, Todd G.
    DEVELOPMENT, 2018, 145 (23):
  • [8] Promotion of the Self-renewal Capacity of Human Acute Leukemia Cells by Wnt3A
    Kawaguchi-Ihara, Noriko
    Murohashi, Ikuo
    Nara, Nobuo
    Tohda, Shuji
    ANTICANCER RESEARCH, 2008, 28 (5A) : 2701 - 2704
  • [9] Cancer Stem Cells and Self-renewal
    O'Brien, Catherine Adell
    Kreso, Antonija
    Jamieson, Catriona H. M.
    CLINICAL CANCER RESEARCH, 2010, 16 (12) : 3113 - 3120
  • [10] The self-renewal signaling pathways utilized by gastric cancer stem cells
    Fu, Ying
    Li, Hui
    Hao, Xishan
    TUMOR BIOLOGY, 2017, 39 (04)
12345