Amino acid substitutions involved in the adaptation of a novel H7N7 avian influenza virus in mice

被引：2
|
作者：
Wu, Haibo [1 ]
Liu, Fumin [1 ]
Yang, Fan [1 ]
Xiao, Yixin [1 ]
Yao, Hangping [1 ]
Wu, Nanping [1 ]
机构：
[1] Zhejiang Univ, State Key Lab Diag & Treatment Infect Dis, Natl Clin Res Ctr Infect Dis,Affiliated Hosp 1,Sc, Natl Med Infect Dis,Collaborat Innovat Ctr Diag &, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China
来源：
RESEARCH IN VETERINARY SCIENCE | 2020年 / 130卷
基金：
美国国家科学基金会;
关键词：
H7N7 avian influenza virus; Genetic variability; Substitutions; Virulence; Mammals; Zoonotic potential; COMMERCIAL POULTRY; A VIRUS; PATHOGENICITY; VIRULENCE; FARMS;
D O I：
10.1016/j.rvsc.2020.03.017
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The H7N7 avian influenza viruses can infect humans and poses a great threat to human health. To identify the amino acid substitutions that are associated with adaptation of avian-origin H7N7 virus to mammals, adaptation of the H7N7 virus was carried out by serial lung-to-lung passage in mice. Genomic analysis of the mouse-adapted virus revealed amino acid changes in the PB2 (E525G, M645I, and D701N), NP (I475V), HA(D103N), and NA(K142E) proteins. The adapted H7N7 virus was more virulent in mice than the wild-type virus. Our results suggest that continued surveillance of poultry populations for these substitutions in the H7N7 virus is required.
引用
收藏
页码：203 / 206
页数：4
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