LC3-Associated Phagocytosis in Bacterial Infection

被引：18
作者：
Yuan, Jin [1 ]
Zhang, Qiuyu [1 ]
Chen, Shihua [1 ]
Yan, Min [1 ]
Yue, Lei [2 ]
机构：
[1] Kunming Med Univ, Fac Basic Med Sci, Dept Pathogen Biol & Immunol, Kunming 650500, Yunnan, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biol, Kunming 650118, Yunnan, Peoples R China
来源：
PATHOGENS | 2022年 / 11卷 / 08期
基金：
中国国家自然科学基金;
关键词：
LC3-associated phagocytosis; bacterial infection; phagocyte; immune evasion; III SECRETION SYSTEM; MYCOBACTERIUM-TUBERCULOSIS; LISTERIA-MONOCYTOGENES; BURKHOLDERIA-PSEUDOMALLEI; LC3; RECRUITMENT; STAPHYLOCOCCUS-AUREUS; NADPH OXIDASE; HOST-DEFENSE; YERSINIA-PSEUDOTUBERCULOSIS; NONCANONICAL AUTOPHAGY;
D O I：
10.3390/pathogens11080863
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
LC3-associated phagocytosis (LAP) is a noncanonical autophagy process reported in recent years and is one of the effective mechanisms of host defense against bacterial infection. During LAP, bacteria are recognized by pattern recognition receptors (PRRs), enter the body, and then recruit LC3 onto a single-membrane phagosome to form a LAPosome. LC3 conjugation can promote the fusion of the LAPosomes with lysosomes, resulting in their maturation into phagolysosomes, which can effectively kill the identified pathogens. However, to survive in host cells, bacteria have also evolved strategies to evade killing by LAP. In this review, we summarized the mechanism of LAP in resistance to bacterial infection and the ways in which bacteria escape LAP. We aim to provide new clues for developing novel therapeutic strategies for bacterial infectious diseases.
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页数：19
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共 112 条
  • [1] Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus
    Abuaita, Basel H.
    Schultz, Tracey L.
    O'Riordan, Mary X.
    [J]. CELL HOST & MICROBE, 2018, 24 (05) : 625 - +
  • [2] ICSB - A SHIGELLA-FLEXNERI VIRULENCE GENE NECESSARY FOR THE LYSIS OF PROTRUSIONS DURING INTERCELLULAR SPREAD
    ALLAOUI, A
    MOUNIER, J
    PREVOST, MC
    SANSONETTI, PJ
    PARSOT, C
    [J]. MOLECULAR MICROBIOLOGY, 1992, 6 (12) : 1605 - 1616
  • [3] Mitochondria in innate immune signaling
    Banoth, Balaji
    Cassel, Suzanne L.
    [J]. TRANSLATIONAL RESEARCH, 2018, 202 : 52 - 68
  • [4] Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
    Baughman, Joshua M.
    Perocchi, Fabiana
    Girgis, Hany S.
    Plovanich, Molly
    Belcher-Timme, Casey A.
    Sancak, Yasemin
    Bao, X. Robert
    Strittmatter, Laura
    Goldberger, Olga
    Bogorad, Roman L.
    Koteliansky, Victor
    Mootha, Vamsi K.
    [J]. NATURE, 2011, 476 (7360) : 341 - U111
  • [5] The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    Bedard, Karen
    Krause, Karl-Heinz
    [J]. PHYSIOLOGICAL REVIEWS, 2007, 87 (01) : 245 - 313
  • [6] Listeria monocytogenes evades killing by autophagy during colonization of host cells
    Birmingham, Cheryl L.
    Canadieni, Veronica
    Gouin, Edith
    Troy, Erin B.
    Yoshimori, Tamotsu
    Cossart, Pascale
    Higgins, Darren E.
    Brumell, John H.
    [J]. AUTOPHAGY, 2007, 3 (05) : 442 - 451
  • [7] Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA
    Campbell-Valois, Francois-Xavier
    Sachse, Martin
    Sansonetti, Philippe J.
    Parsot, Claude
    [J]. MBIO, 2015, 6 (03): : 1 - 11
  • [8] Mycobacterium marinum induces a marked LC3 recruitment to its containing phagosome that depends on a functional ESX-1 secretion system
    Cecilia Lerena, Maria
    Isabel Colombo, Maria
    [J]. CELLULAR MICROBIOLOGY, 2011, 13 (06) : 814 - 835
  • [9] Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages
    Chandra, Pallavi
    Ghanwat, Swapnil
    Matta, Sumit Kumar
    Yadav, Swati Seth
    Mehta, Mansi
    Siddiqui, Zaved
    Singh, Amit
    Kumar, Dhiraj
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [10] The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation
    Choy, Augustine
    Dancourt, Julia
    Mugo, Brian
    O'Connor, Tamara J.
    Isberg, Ralph R.
    Melia, Thomas J.
    Roy, Craig R.
    [J]. SCIENCE, 2012, 338 (6110) : 1072 - 1076
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