Cellular cross-talks in the diseased and aging heart

被引：56

作者：

Wagner, Julian U. G. ^{[1
,2
,4
]}

Dimmeler, Stefanie ^{[1
,2
,3
]}

机构：

[1] Goethe Univ, Inst Cardiovasc Regenerat, Theodor Stern Kai 7, Frankfurt, Germany

[2] German Ctr Cardiovasc Res DZHK, Frankfurt, Germany

[3] CPI, Frankfurt, Germany

[4] Goethe Univ, Fac Biol Sci, Frankfurt, Germany

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2020年 / 138卷

关键词：

GROWTH-FACTOR-I; RESIDENT CARDIAC MACROPHAGES; TRANSCRIPTION FACTOR FOXO3A; AGE-RELATED-CHANGES; NITRIC-OXIDE; MESENCHYMAL TRANSITION; CLONAL HEMATOPOIESIS; MYOCARDIAL-ISCHEMIA; STEM-CELLS; CARDIOMYOCYTE CROSSTALK;

D O I：

10.1016/j.yjmcc.2019.11.152

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Communication between cells is an important, evolutionarily conserved mechanism which enables the coordinated function of multicellular organisms. Heterogeneity within cell populations drive a remarkable network of cellular cross-talk that allows the heart to function as an integrated unit with distinct tasks allocated to sub-specialized cells. During diseases and aging, cells acquire an overt disordered state that significantly contributes to an altered cellular cross-talk and hence drive cardiac remodeling processes and cardiovascular diseases. However, adaptive mechanisms, and phenotypic changes in subpopulations of cells (e.g. reparative macrophages or fibroblasts) can also contribute to repair and regeneration. In this article, we review the cellular cross-talks between immune cells, endothelial cells, fibroblasts and cardiomyocytes that control heart failure by contributing to cardiac dysfunction and aging, or by mediating repair and regeneration of the heart after injury.

引用

页码：136 / 146

页数：11

共 180 条

[41] CCR5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart, Mediating Recruitment of Regulatory T Cells [J].

Dobaczewski, Marcin ;

Xia, Ying ;

Bujak, Marcin ;

Gonzalez-Quesada, Carlos ;

Frangogiannis, Nikolaos G. .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (05) :2177-2187

[42] Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure [J].

Domenighetti, AA ;

Wang, Q ;

Egger, M ;

Richards, SM ;

Pedrazzini, T ;

Delbridge, LMD .

HYPERTENSION, 2005, 46 (02) :426-432

[43] Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic lschemic Heart Failure [J].

Dorsheimer, Lena ;

Assmus, Birgit ;

Rasper, Tina ;

Ortmann, Christina A. ;

Ecke, Andreas ;

Abou-El-Ardat, Khalil ;

Schmid, Tobias ;

Bruene, Bernhard ;

Wagner, Sebastian ;

Serve, Hubert ;

Hoffmann, Jedrzej ;

Seeger, Florian ;

Dimmeler, Stefanie ;

Zeiher, Andreas M. ;

Rieger, Michael A. .

JAMA CARDIOLOGY, 2019, 4 (01) :25-33

[44] ATROPHY OF SKELETAL MUSCLE IN CHICK EMBRYOS TREATED WITH BOTULINUM TOXIN [J].

DRACHMAN, DB .

SCIENCE, 1964, 145 (363) :719-&

[45]

Drobczyk M, 2017, INT CONF WIREL SPAC, P57, DOI 10.1109/WiSEE.2017.8124893

[46] Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice [J].

Edgar, Daniel ;

Shabalina, Irina ;

Camara, Yolanda ;

Wredenberg, Anna ;

Calvaruso, Maria Antonietta ;

Nijtmans, Leo ;

Nedergaard, Jan ;

Cannon, Barbara ;

Larsson, Nils-Goeran ;

Trifunovic, Aleksandra .

CELL METABOLISM, 2009, 10 (02) :131-138

[47] Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation [J].

Epelman, Slava ;

Lavine, Kory J. ;

Beaudin, Anna E. ;

Sojka, Dorothy K. ;

Carrero, Javier A. ;

Calderon, Boris ;

Brija, Thaddeus ;

Gautier, Emmanuel L. ;

Ivanov, Stoyan ;

Satpathy, Ansuman T. ;

Schilling, Joel D. ;

Schwendener, Reto ;

Sergin, Ismail ;

Razani, Babak ;

Forsberg, E. Camilla ;

Yokoyama, Wayne M. ;

Unanue, Emil R. ;

Colonna, Marco ;

Randolph, Gwendalyn J. ;

Mann, Douglas L. .

IMMUNITY, 2014, 40 (01) :91-104

[48] Good and bad sides of TGFβ-signaling in myocardial infarction [J].

Euler, Gerhild .

FRONTIERS IN PHYSIOLOGY, 2015, 6

[49] Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability [J].

Evrard, Solene M. ;

Lecce, Laura ;

Michelis, Katherine C. ;

Nomura-Kitabayashi, Aya ;

Pandey, Gaurav ;

Purushothaman, K-Raman ;

d'Escamard, Valentina ;

Li, Jennifer R. ;

Hadri, Lahouaria ;

Fujitani, Kenji ;

Moreno, Pedro R. ;

Benard, Ludovic ;

Rimmele, Pauline ;

Cohain, Ariella ;

Mecham, Brigham ;

Randolph, Gwendalyn J. ;

Nabel, Elizabeth G. ;

Hajjar, Roger ;

Fuster, Valentin ;

Boehm, Manfred ;

Kovacic, Jason C. .

NATURE COMMUNICATIONS, 2016, 7

[50] Single-cell expression profiling reveals dynamic flux of cardiac stromal,vascular and immune cells in health and injury [J].

Farbehi, Nona ;

Patrick, Ralph ;

Dorison, Aude ;

Xaymardan, Munira ;

Janbandhu, Vaibhao ;

Wystub-Lis, Katharina ;

Ho, Joshua W. K. ;

Nordon, Robert E. ;

Harvey, Richard P. .

ELIFE, 2019, 8

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