Preparation and Properties of Poly(D,L-lacticie-co-glycolide- co-ε-caprolactone)/1,4-Butanendimine Modified Poly(lactide-co-glycolide) Blend Porous Microspheres

被引：9

作者：

Gu, Jiaming ^{[1
]}

Zhou, Zhihua ^{[1
,2
,3
]}

Huang, Tianlong ^{[4
]}

Wu, Wei ^{[5
]}

Liu, Wenjuan ^{[2
]}

Zhao, Yanmin ^{[1
]}

Chen, Ping ^{[1
]}

Zhou, Ziwei ^{[1
]}

Wang, Dan ^{[1
]}

Zhang, Chao ^{[1
]}

Yi, Meilin ^{[1
]}

He, Xiao ^{[1
]}

Fang, Jianjun ^{[1
]}

机构：

[1] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China

[2] Hunan Univ Sci & Technol, Hunan Prov Key Lab Controllable Preparat & Funct, Xiangtan, Peoples R China

[3] Hunan Univ Sci & Technol, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Xiangtan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 2, Dept Orthoped, Changsha, Peoples R China

[5] Daqing Petrochem Res Inst CNPC, Daqing, Peoples R China

来源：

JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS | 2022年 / 61卷 / 02期

关键词：

1,4-butanediamine modified poly(lactide-co-glycolide)cytocompatibility; in-vitro degradation; poly(lactide-co-glycolide-co-epsilon-caprolactone); porous microspheres; EPSILON-CAPROLACTONE MICROSPHERES; IN-VITRO; PLGA MICROPARTICLES; SYNTHETIC-POLYMERS; MALEIC-ANHYDRIDE; BEHAVIOR; RELEASE; ACID;

D O I：

10.1080/00222348.2021.2002457

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Composite porous microspheres based on blends of poly(D,L-lactide-co-glycolide-co-epsilon-caprolactone) (PLGCL) and 1,4-butanediamine modified poly(D,L-lactide-co-glycolide) (BMPLGA) were prepared by using a combined solvent evaporation and particle leaching technique. The morphologies and porous structure of the PLGCL/BMPLGA microspheres were observed by using scanning electron microscopy (SEM). The in-vitro degradation behaviors and cytocompatibility were studied. The resultant microspheres showed a porous surface and a three-dimensional network structure with interconnecting pores. The changes of morphologies, pH value and mass loss during in-vitro degradation in phosphate buffered solution (PBS) at 37 degrees C indicated that the degradation rate of the BMPLGA was faster than that of the PLGCL in the PLGCL/BMPLGA blends. We suggest the PLGCL/BMPLGA porous microspheres were non-cytotoxic and showed excellent cytocompatibility. We suggest the PLGCL/BMPLGA porous polymeric microspheres have great potential for application for drugs delivery and tissue regeneration.

引用

页码：270 / 280

页数：11

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